Fig. 3
From: Meta-Apo improves accuracy of 16S-amplicon-based prediction of microbiome function
Functional beta diversity of the 622 WGS:16S-amplicon sample pairs from Dataset 1. a Overall functional patterns derived from the amplicon and WGS approaches are isomorphic but separate with significant differences on PC1 and PC2 distributions. b Bray-Curtis distances calculated by WGS and amplicons are strongly correlated (Pearson correlation R = 0.86, p < 0.01). c Meta-Apo aligns the predicted functional profiles derived from amplicon samples to those of WGS samples using 15 sample pairs for training, making the PC1 and PC2 of calibrated functional profiles are closer to WGS samples than the original, non-calibrated amplicon samples. d ∆PC of the WGS:16S amplicon pairs were significantly reduced. Principle coordinates were calculated by PCoA using the Bray-Curtis distances. The p-values were calculated by two-tail paired Wilcox tests, and *** denotes p < 0.01