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Table 4 List of candidate genes with highest posterior probability of causality (PPC) and their minimum P-values for casualty (M_Causality) and GWAS (M_GWAS) associated with hypocalcemia (CALC), displaced abomasum (DSAB), ketosis (KETO), mastitis (MAST), metritis (METR), retained placenta (RETP) and cow livability and their tissue specific expression

From: GWAS and fine-mapping of livability and six disease traits in Holstein cattle

TraitGeneChrStartEndM_GWAS
P-value
M_Casualty
P-value
PPCTypeTissue-Specific Expression
DSABPLXNA4496,574,36997,120,7184.5 × 10−76.5 × 10−70.49protein_codingAorta, Liver, Trachea
DSABFANCC883,022,52283,228,6961.3 × 10−72.1 × 10−90.79protein_codingThyroid
DSABNTM2935,153,01236,117,7261.3 × 10−71.7 × 10− 70.99protein_codingCentral Nervous System
LOC107133096142,760,0932,762,8782.0 × 10−95.9 × 10−80.92IncRNA
KETOPARP10142,024,5092,031,4777.0 × 10−71.7 × 10−50.16protein_coding
DGAT1141,795,4251,804,8381.0 × 10−61.7 × 10−50.08protein_codingBone Marrow
KETOLOC783947167,050,4457,055,0211.9 × 10−81.3 × 10−81.00lncRNA
MASTGC688,687,84588,739,2922.0 × 10−71.2 × 10−70.15protein_codingKidney, Cortex, Liver
METRCOBL44,494,9254,795,9044.3 × 10−37.7 × 10−41.00protein_coding
LOC100296627432,573,07932,613,2377.6 × 10−74.0 × 10−131.00protein_coding
RETPMALSU1432,051,59032,077,0367.5 × 10−41,1 × 10−130.98protein_coding
ABCB1433,013,20833,095,7086.3 × 10−18.4 × 10−30.28protein_coding
RETPTMEM182117,449,5197,492,8719.0 × 10−89.9 × 10−80.96protein_codingHeart, Muscle, Tongue
RETPLOC7834931863,799,60863,803,2138.3 × 10−31.2 × 10−50.94Pseudogene
LivabilityABCC958,867,204788,834,4911.5 × 10−101.5 × 10−101.00protein_codingAorta, Atrium, Lung, Muscle
Uterine myometrium, Ventricle
LivabilityGC688,687,84588,739,2921.9 × 10−171.4 × 10− 190.03protein_codingKidney, Cortex, Liver
LivabilityZFAT148,144,7748,305,7752.1 × 10−53.2 × 10−50.23protein_coding
LivabilityLOC6184631857,587,99057,594,5491.7 × 10−203.1 × 10−200.20protein_coding
LivabilityCCDC88C2156,645,62956,773,4388.6 × 10−118.9 × 10−110.95protein_codingCD8_cell
LivabilityLOC1019086672325,904,08425,909,4612.1 × 10−87.9 × 10−90.31lncRNA