Table 2 The 20 most downregulated genes in IMF versus SC (log2 normalised mean expression). P values are reported for both DE and PIF (based on the SC versus IMF comparison)
Gene | Probe | LD | IMF | SC | Function | P value (DE / PIF) |
|---|---|---|---|---|---|---|
SCD | A_73_P252739 | 14.46 | 15.33 | 16.47 | Desaturation, fatty acid synthesis (oleic acid) | 0.000153 / 0.00000163 |
TF | A_73_109609 | 9.57 | 11.04 | 12.47 | Iron transport | 0.00000421 / 0.00000731 |
CXCL3 | A_73_108688 | 11.34 | 12.09 | 13.36 | Secreted growth factor, inflammation | 0.0000332 / 0.0000151 |
DGAT2 | A_73_118582 | 14.51 | 15.86 | 16.72 | Final reaction in TAG synthesis | 0.00259 / 0.000132 |
PCK2 | A_73_P102501 | 12.44 | 13.49 | 14.44 | Adipogenesis, mitochondrial | 0.00112 / 0.0003 |
RAB9B | A_73_104413 | 12.83 | 14.19 | 15.09 | Endosome to golgi transport, membrane trafficking | 0.00180 / 0.000326 |
CFB | A_73_118840 | 10.91 | 11.98 | 12.98 | Complement factor B | 0.000681 / 0.000528 |
FASN | A_73_P174332 | 16.08 | 17.23 | 17.94 | Synthesis of long chain saturated fatty acids | 0.00918 / 0.000528 |
ACSS2 | A_73_P037091 | 12.58 | 13.11 | 14.01 | Activation of acetate for lipid synthesis | 0.00180 / 0.000670 |
TDH | A_73_P042901 | 5.99 | 6.49 | 8.11 | Catalyses l-threonine degradation | 0.00117 / 0.000919 |
CD163 | A_73_P091466 | 7.18 | 7.81 | 9.20 | Inflammation, strongly expressed by macrophages | 0.00000719 / 0.000928 |
G0S2 | A_73_100624 | 13.72 | 15.16 | 15.91 | FA, TAG and ketone metabolism | 0.00666 / 0.00106 |
TIMP4 | A_73_112376 | 14.43 | 14.97 | 15.73 | Inhibitor of matrix metalloproteinases | 0.00614 / 0.00105 |
AGPAT2 | A_73_118412 | 17.80 | 18.26 | 18.89 | De novo phospholipid synthesis, endoplasmic reticulum | 0.0168 / 0.00102 |
CCDC80 | A_73_P035251 | 15.24 | 16.08 | 16.79 | Extracellular matrix | 0.00918 / 0.00119 |
QPRT | A_73_P039661 | 11.69 | 12.80 | 13.62 | NAD de novo biosynthesis | 0.00370 / 0.00204 |
SPARC | A_73_P300606 | 17.10 | 17.85 | 18.43 | Extracellular matrix organisation | 0.0239 / 0.00258 |
CIDEA | A_73_100290 | 12.16 | 12.84 | 13.64 | Regulation of lipolysis | 0.00439 / 0.00245 |