Table 3 Genes more highly expressed in IMF than all other fat depots by at least 1.32 fold whose expression appears driven by marbling adipocytes (IMF expression greater than 2 fold higher than LD). Normalised expression data expressed as log2 values. P values are reported for both DE and PIF (based on the SC versus IMF comparison)
Gene | Probe | LD | IMF | SC | Inter | Kid | Omen | Function | P value (DE / PIF) |
|---|---|---|---|---|---|---|---|---|---|
CNN1 | A_73_116127 | 12.93 | 14.22 | 12.84 | 13.20 | 12.98 | 12.88 | Calponin 1, cytoskeleton | 0.0000974 / 0.00000727 |
ACTA2 | A_73_102355 | 15.75 | 16.79 | 15.69 | 15.96 | 15.88 | 15.78 | Actin alpha 2, cytoskeleton | 0.00180 / 0.0000175 |
MYH11 | A_73_103577 | 13.12 | 14.33 | 13.03 | 13.31 | 13.16 | 13.06 | Myosin heavy chain 11, cytoskeleton | 0.000239 / 0.0000191 |
ACTB | A_73_P082186 | 10.63 | 12.12 | 10.64 | 11.09 | 10.85 | 10.68 | Actin beta, cytoskeleton | 0.0000295 / 0.000000000212 |
CH25H | A_73_113925 | 9.18 | 10.53 | 9.01 | 9.83 | 9.69 | 9.82 | Cholesterol 25 hydroxylase, inflammation, lipid metabolism | 0.0000179 / 0.000334 |
ACTRT2 | A_73_107737 | 7.99 | 9.25 | 7.78 | 8.26 | 8.04 | 8.40 | Actin related protein T2 | 0.0000334 / 0.00230 |
INHBA | A_73_108840 | 8.04 | 9.18 | 7.72 | 8.27 | 7.94 | 8.32 | Inhibin A, Growth and Differentiation Factor, Hormone, binds ACVR2A | 0.0000377 / 0.00283 |
SORBS2 | A_73_P046131 | 10.85 | 12.12 | 11.06 | 11.27 | 11.15 | 11.27 | Sorbin and SH3 domain containing. Cytoskeleton, lipid raft interaction | 0.0026 / 0.00301 |
NDRG4 | A_73_109411 | 9.76 | 10.80 | 9.63 | 9.92 | 9.91 | 9.82 | Many developmental processes, ERK signalling, plasma membrane | 0.000922 / 0.00352 |
TNC | A_73_108252 | 8.03 | 9.22 | 7.83 | 8.67 | 8.09 | 7.87 | Tenascin, extracellular matrix | 0.0000867 / 0.00379 |
RAMP3 | A_73_P043356 | 6.56 | 7.92 | 6.34 | 7.03 | 6.69 | 6.81 | Trans-membrane, transports calcitonin receptor-like protein | 0.00000824 / 0.00577 |
TNMD | A_73_110381 | 6.16 | 7.19 | 5.51 | 6.45 | 5.34 | 5.33 | Tenomodulin, genetic variants associated with type II diabetes | 0.00000212 / 0.00829 |
KRT18 | A_73_118812 | 5.99 | 7.39 | 5.77 | 6.04 | 5.83 | 6.68 | Keratin 18, cytoskeleton | 0.00000484 / 0.0087 |
CTPS2 | A_73_113928 | 13.04 | 14.25 | 13.55 | 13.63 | 13.46 | 13.50 | CTP synthase 2, rate limiting enzyme for CTP production from UTP. | 0.0404 / 0.0157 |
TAGLN | A_73_P291026 | 9.36 | 10.43 | 9.51 | 9.90 | 9.67 | 9.72 | Transgelin, actin cross-linking | 0.0085 / 0.0186 |
GJA5 | A_73_P048871 | 9.66 | 10.69 | 9.80 | 10.20 | 10.23 | 10.23 | Connexin gene family, plasma membrane | 0.0107 / 0.0147 |
DKK3 | A_73_116904 | 10.33 | 11.58 | 10.77 | 11.13 | 11.12 | 10.96 | Wnt signalling, many developmental processes | 0.0194 / 0.0236 |
MKX | A_73_105199 | 5.25 | 6.34 | 4.97 | 5.75 | 4.96 | 5.11 | Collagen biosynthesis | 0.000109 / 0.0490 |
MIR145 | A_73_105615 | 12.31 | 13.61 | 13.04 | 13.07 | 12.96 | 13.01 | microRNA, little known | 0.0857 / 0.0515 |
COL28A1 | A_73_107519 | 4.90 | 6.28 | 4.93 | 5.42 | 5.49 | 5.05 | Extracellular matrix | 0.0137 / 0.0540 |