Table 4 Gene expression patterns of those genes identified by multiple criteria (>2 fold higher expression in IMF than SC and also higher expression in IMF than LD) that encode proteins involved in cholesterol metabolism, retinoic acid metabolism and carbohydrate metabolism. CH25H not shown here as its expression profile is documented in Table 3 (all values are log2 normalised mean expression). P values are reported for both DE and PIF (based on the SC versus IMF comparison)
Gene | Probe | LD | IMF | SC | Inter | Kid | Omen | Function | P value (DE / PIF) |
|---|---|---|---|---|---|---|---|---|---|
PMP2 | A_73_110378 | 3.74 | 5.44 | 3.90 | 3.78 | 3.74 | 3.72 | Alias FABP8. Cholesterol binding. Found in cytoplasm, extracellular exosomes and myelin sheath | 0.0000138 / 0.0643 |
CYP4B1 | A_73_P033761 | 7.54 | 8.12 | 7.05 | 8.30 | 7.36 | 7.89 | Member of the cytochrome p450 superfamily that synthesises cholesterol, steroids and other lipids. Found in the endoplasmic reticulum. | 0.00238 / 0.0396 |
STRA6 | A_73_106763 | 4.22 | 5.33 | 3.99 | 4.37 | 4.21 | 5.27 | Membrane protein involved in the metabolism of retinol involved in numerous developmental processes in many tissues. | 0.000154 / 0.0969 |
MEST | A_73_100042 | 7.27 | 7.79 | 6.62 | 7.25 | 6.87 | 7.06 | Regulation of lipid storage and response to retinoic acid. Found in the endoplasmic reticulum, extracellular exosome and membrane. | 0.00092 / 0.0335 |
GRB14 | A_73_114416 | 5.13 | 5.73 | 4.61 | 5.04 | 5.33 | 5.46 | Interacts with insulin receptors and insulin-like growth factor receptors, having an inhibitory effect. | 0.00149 / 0.1172 |
NR4A3 | A_73_P494813 | 5.57 | 6.19 | 5.11 | 6.04 | 5.85 | 6.08 | Member of the steroid thyroid hormone retinoid receptor superfamily. | 0.00217 / 0.102 |
MOXD1 | A_73_104693 | 4.16 | 5.09 | 4.06 | 4.44 | 4.47 | 4.87 | Monoxygenase, localised to the endoplasmic reticulum and cell membrane | 0.0034 / 0.177 |