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Fig. 1 | BMC Genomics

Fig. 1

From: Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928–2013): antimicrobial use/misuse selects for resistance and drives evolution

Fig. 1

Treatment guidelines and antimicrobial resistance development in Denmark since the 1920s. a Coloured arrows indicate the time period the different antimicrobials were recommended and used for treatment of gonorrhoea in Denmark. b Mean MIC of antimicrobials previously and currently used for treatment of gonorrhoea (2–4 antimicrobials per box) and first identification of antimicrobial resistance determinants for the specific antimicrobials in the examined isolates from Denmark (black arrow)

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