Skip to main content

Table 2 IPA summary of liver transcriptomes in hatchling chicks-D2FED48h vs. D2FAST48h contrast

From: Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription factor

Top Canonical Pathwaysp-valueOverlapRatio
Superpathway of Cholesterol Biosynthesis1.36E-0942.9%12/28
Protein Ubiquitination Pathway2.83E-0813.3%34/255
Tryptophan Degradation III (Eukaryotic)1.65E-0742.9%9/21
NRF2-mediated Oxidative Stress Response2.46E-0714.4%26/180
Cholesterol Biosynthesis I5.92E-0753.8%7/13
Top Upstream Regulatorsp-value of overlap# Target genes
HNF4A1.32E-24174
PPARA1.48E-2469
TP532.81E-19119
NFE2L23.18E-1551
MYC1.73E-1495
Top Molecular and Cellular Functionsp-value# Genes
Lipid Metabolism1.83E-03 - 3.91E-15195
Small Molecule Biochemistry2.08E-03 - 3.91E-15277
Cell Cycle2.07E-03 - 1.26E-11175
Amino Acid Metabolism2.08E-03 - 4.78E-1141
Cell Death and Survival1.13E-03 - 5.19E-1131
Physiological System Development and Functionp-value# Genes
Tissue Morphology2.00E-03 - 4.53E-0692
Tissue Development1.77E-03 - 9.24E-0676
Connective Tissue Development and Function2.00E-03 - 1.09E-05116
Organismal Survival2.13E-05 - 2.13E-05200
Organismal Development1.77E-03 - 4.61E-0528
Top up-regulated genesD2FED48h/D2FAST48hTop down-regulated genesD2FED48h/D2FAST48h
THRSPA6.19IGFBP2−3.45
ME14.74ADSL−3.18
SCD4.74CYP3A7−3.07
FADS23.63CYP4A22−2.74
LGALS23.47CYP2C44−2.66
CYP2C443.24LDHB−2.62
PLIN23.23UPP2−2.48
MSMO12.49EHHADH−2.41
ELOVL62.43HADHB−2.31
INSIG12.33BHMT−2.15
  1. Ingenuity Pathway Analysis (IPA) was used for functional analysis of 968 Analysis Ready (AR)-DEGs from the D2FED48h vs. D2FAST48h contrast. The top 10 up-regulated and down-regulated AR-DEGs are presented along with their respective log2 ratio of treatment conditions