Table 2 IPA summary of liver transcriptomes in hatchling chicks-D2FED48h vs. D2FAST48h contrast
Top Canonical Pathways | p-value | Overlap | Ratio |
|---|---|---|---|
Superpathway of Cholesterol Biosynthesis | 1.36E-09 | 42.9% | 12/28 |
Protein Ubiquitination Pathway | 2.83E-08 | 13.3% | 34/255 |
Tryptophan Degradation III (Eukaryotic) | 1.65E-07 | 42.9% | 9/21 |
NRF2-mediated Oxidative Stress Response | 2.46E-07 | 14.4% | 26/180 |
Cholesterol Biosynthesis I | 5.92E-07 | 53.8% | 7/13 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
HNF4A | 1.32E-24 | 174 | |
PPARA | 1.48E-24 | 69 | |
TP53 | 2.81E-19 | 119 | |
NFE2L2 | 3.18E-15 | 51 | |
MYC | 1.73E-14 | 95 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Lipid Metabolism | 1.83E-03 - 3.91E-15 | 195 | |
Small Molecule Biochemistry | 2.08E-03 - 3.91E-15 | 277 | |
Cell Cycle | 2.07E-03 - 1.26E-11 | 175 | |
Amino Acid Metabolism | 2.08E-03 - 4.78E-11 | 41 | |
Cell Death and Survival | 1.13E-03 - 5.19E-11 | 31 | |
Physiological System Development and Function | p-value | # Genes | |
Tissue Morphology | 2.00E-03 - 4.53E-06 | 92 | |
Tissue Development | 1.77E-03 - 9.24E-06 | 76 | |
Connective Tissue Development and Function | 2.00E-03 - 1.09E-05 | 116 | |
Organismal Survival | 2.13E-05 - 2.13E-05 | 200 | |
Organismal Development | 1.77E-03 - 4.61E-05 | 28 | |
Top up-regulated genes | D2FED48h/D2FAST48h | Top down-regulated genes | D2FED48h/D2FAST48h |
THRSPA | 6.19 | IGFBP2 | −3.45 |
ME1 | 4.74 | ADSL | −3.18 |
SCD | 4.74 | CYP3A7 | −3.07 |
FADS2 | 3.63 | CYP4A22 | −2.74 |
LGALS2 | 3.47 | CYP2C44 | −2.66 |
CYP2C44 | 3.24 | LDHB | −2.62 |
PLIN2 | 3.23 | UPP2 | −2.48 |
MSMO1 | 2.49 | EHHADH | −2.41 |
ELOVL6 | 2.43 | HADHB | −2.31 |
INSIG1 | 2.33 | BHMT | −2.15 |