Table 5 IPA summary of liver transcriptomes in hatchling chicks-D2FAST48h vs. D4REFED48h contrasta
Top Canonical Pathways | p-value | Overlap | Ratio |
|---|---|---|---|
Super-pathway of Cholesterol Biosynthesis | 7.68E-10 | 39.3% | 11/28 |
Tryptophan Degradation III | 3.74E-09 | 40.0% | 10/25 |
Sirtuin Signaling Pathway | 6.93E-08 | 10.3% | 30/292 |
Cholesterol Biosynthesis I-II | 6.99E-08 | 53.8% | 7/13 |
LPS/IL-1 Mediated Inhibition of RXR Function | 5.58E-07 | 10.8% | 24/222 |
Top Upstream Regulators predicted by IPA | p-value of overlap | # Target genes | |
PPARA | 1.41E-20 | 62 | |
NFE2L2 | 1.09E-14 | 50 | |
HNF4A | 3.61E-12 | 134 | |
PPARGC1A | 4.21E-12 | 34 | |
SREBF2 | 5.77E-12 | 19 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Lipid Metabolism | 1.23E-03 - 6.04E-16 | 181 | |
Molecular Transport | 1.28E-03 - 6.04E-16 | 190 | |
Small Molecule Biochemistry | 1.28E-03 - 6.04E-16 | 237 | |
Vitamin and Mineral Metabolism | 1.14E-03 - 5.30E-14 | 64 | |
Amino Acid Metabolism | 1.14E-03 - 3.22E-10 | 38 | |
Physiological System Development and Function | p-value | # Genes | |
Digestive System Development and Function | 1.14E-03 - 6.09E-09 | 87 | |
Hepatic System Development and Function | 1.14E-03 - 6.09E-09 | 67 | |
Organ Morphology | 7.07E-04 - 6.09E-09 | 46 | |
Organismal Development | 1.22E-03 - 6.09E-09 | 147 | |
Embryonic Development | 1.22E-03 - 3.24E-08 | 55 | |
Up-regulated genes | FAST48h/REFED48h | Down-regulated genes | FAST48h/REFED48h |
IGFBP2 | 3.31 | THRSPA | −6.47 |
ADSL | 3.21 | ME1 | −4.97 |
CYP3A7 | 2.51 | SCD | −4.55 |
CYP4A22 | 2.39 | LGALS2 | −4.14 |
BHMT | 2.34 | PLIN2 | −3.64 |
AIF1L | 2.31 | FADS2 | −3.86 |
LDHB | 2.16 | CYP51A1 | −3.56 |
ABCG5 | 2.06 | DIO2 | −2.71 |
NDRG1 | 2.04 | ENOVL6 | −2.59 |
AKR1D1 | 1.97 | MSMO1 | −2.58 |