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Table 5 IPA summary of liver transcriptomes in hatchling chicks-D2FAST48h vs. D4REFED48h contrasta

From: Transcriptome analyses of liver in newly-hatched chicks during the metabolic perturbation of fasting and re-feeding reveals THRSPA as the key lipogenic transcription factor

Top Canonical Pathwaysp-valueOverlapRatio
Super-pathway of Cholesterol Biosynthesis7.68E-1039.3%11/28
Tryptophan Degradation III3.74E-0940.0%10/25
Sirtuin Signaling Pathway6.93E-0810.3%30/292
Cholesterol Biosynthesis I-II6.99E-0853.8%7/13
LPS/IL-1 Mediated Inhibition of RXR Function5.58E-0710.8%24/222
Top Upstream Regulators predicted by IPAp-value of overlap# Target genes
PPARA1.41E-2062
NFE2L21.09E-1450
HNF4A3.61E-12134
PPARGC1A4.21E-1234
SREBF25.77E-1219
Top Molecular and Cellular Functionsp-value# Genes
Lipid Metabolism1.23E-03 - 6.04E-16181
Molecular Transport1.28E-03 - 6.04E-16190
Small Molecule Biochemistry1.28E-03 - 6.04E-16237
Vitamin and Mineral Metabolism1.14E-03 - 5.30E-1464
Amino Acid Metabolism1.14E-03 - 3.22E-1038
Physiological System Development and Functionp-value# Genes
Digestive System Development and Function1.14E-03 - 6.09E-0987
Hepatic System Development and Function1.14E-03 - 6.09E-0967
Organ Morphology7.07E-04 - 6.09E-0946
Organismal Development1.22E-03 - 6.09E-09147
Embryonic Development1.22E-03 - 3.24E-0855
Up-regulated genesFAST48h/REFED48hDown-regulated genesFAST48h/REFED48h
IGFBP23.31THRSPA−6.47
ADSL3.21ME1−4.97
CYP3A72.51SCD−4.55
CYP4A222.39LGALS2−4.14
BHMT2.34PLIN2−3.64
AIF1L2.31FADS2−3.86
LDHB2.16CYP51A1−3.56
ABCG52.06DIO2−2.71
NDRG12.04ENOVL6−2.59
AKR1D11.97MSMO1−2.58
  1. aIngenuity Pathway Analysis (IPA) was used for functional analysis of 750 “Analysis Ready” (AR)-DEGs from the D2FAST48h vs. D4REFED48h contrast. The top 10 up-regulated and down-regulated AR-DEGs are presented along with their respective log2 ratio of treatment conditions, where positive numbers indicate higher expression in the D2FAST48h treatment and negative values indicate higher expression in the D4REFED48h treatment condition