Table 2 List of exclusions from consideration as a reference miRNA based on the known, experimentally validated connections

hsa-miR-222

Gastric cancer

[45]

hsa-miR-92a

Acute myeloid leukemia, acute myocardial infarction, potential marker of atherosclerosis, metabolic syndrome, bladder cancer, systemic lupus erythematosus

[46,47,48,49]

hsa-miR-27a

Acute pulmonary embolism, colorectal cancer

[52, 61]

hsa-miR-17

Elevated in many types of cancer, acute ischemic stroke, endometriosis, acute myocardial infarction

[62,63,64]

hsa-miR-24

Coronary heart disease, type 2 diabetes mellitus, early breast cancer

[65, 66]

hsa-miR-320a

Esophageal adenocarcinoma, Barret’s esophagus, arrhythmogenic cardiomyopathy

[67, 68]

hsa-miR-25

Osteosarcoma, breast cancer, papillary thyroid carcinoma, pancreatic cancer, gastric cancer, hepatocellular carcinoma, esophageal adenocarcinoma

[69,70,71,72,73,74]

hsa-miR-126

Non-small-cell lung cancer, chronic heart failure, acute myocardial infarction, ischemic stroke, type 2 diabetes mellitus

[64, 75,76,77,78]

hsa-miR-19b

Knee osteoarthritis, diabetic cardiomyopathy, acute myocardial infarction, gastric cancer, prostate cancer, lung cancer

[79,80,81,82,83,84]

hsa-miR-199a

Glioma, hepatocellular carcinoma, acute myocardial infarction, colorectal cancer, osteosarcoma

[85,86,87,88,89]

hsa-miR-30b

Active tuberculosis

[90]

hsa-miR-30c

HLTV-1 infection, Duchenne muscular dystrophy, active pulmonary tuberculosis

[91,92,93]

hsa-miR-374

Acute Graft-versus-Host disease

[94]