Table 7 ECEA identified equivalently changed Reactome pathways in the antidepressant data
Pathway | FDR | NES | Size | Top 5 Genes |
|---|---|---|---|---|
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 2.76 × 10−2 | 1.38 | 78 | Gpc3,Trf,Scg3,Penk,F5 |
Post-translational protein phosphorylation | 3.02 × 10−2 | 1.38 | 73 | Gpc3,Trf,Scg3,Penk,F5 |
GPCR ligand binding | 1.14 × 10−1 | 1.22 | 200 | Mc3r,Sstr5,Crhr2,Glp1r,Nts |
L13a-mediated translational silencing of Ceruloplasmin expression | 8.07 × 10−3 | 1.39 | 100 | Rpsa,Rpl34,Rplp1,Rps29,Rpl8 |
Eukaryotic Translation Initiation | 8.07 × 10− 3 | 1.35 | 108 | Rpsa,Rpl34,Rplp1,Rps29,Rpl8 |
Formation of a pool of free 40S subunits | 8.07 × 10−3 | 1.45 | 90 | Rpsa,Rpl34,Rplp1,Rps29,Rpl8 |
GTP hydrolysis and joining of the 60S ribosomal subunit | 1.48 × 10−2 | 1.38 | 101 | Rpsa,Rpl34,Rplp1,Rps29,Rpl8 |
Cap-dependent Translation Initiation | 8.07 × 10−3 | 1.35 | 108 | Rpsa,Rpl34,Rplp1,Rps29,Rpl8 |
Translation | 3.02 × 10−2 | 1.23 | 211 | Mrpl10,Mrps16,Rpsa,Rpl34,Rplp1 |
SRP-dependent cotranslational protein targeting to membrane | 8.07 × 10−3 | 1.53 | 81 | Rpsa,Rpl34,Rplp1,Rps29,Rpl8 |
Major pathway of rRNA processing in the nucleolus and cytosol | 8.07 × 10−3 | 1.36 | 156 | Exosc10,Rpsa,Rpl34,Rplp1,Rps29 |
rRNA processing | 8.07 × 10−3 | 1.36 | 156 | Exosc10,Rpsa,Rpl34,Rplp1,Rps29 |
rRNA processing in the nucleus and cytosol | 8.07 × 10−3 | 1.36 | 156 | Exosc10,Rpsa,Rpl34,Rplp1,Rps29 |
Nonsense-Mediated Decay (NMD) | 8.07 × 10−3 | 1.44 | 102 | Upf2,Rpsa,Rpl34,Rplp1,Rps29 |
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.07 × 10−3 | 1.51 | 83 | Rpsa,Rpl34,Rplp1,Rps29,Rpl8 |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.07 × 10−3 | 1.44 | 102 | Upf2,Rpsa,Rpl34,Rplp1,Rps29 |
Sulfur amino acid metabolism | 8.07 × 10−3 | 1.74 | 19 | Slc25a10,Gm4737,Ahcy,Cdo1,Adi1 |