Skip to main content

Table 7 ECEA identified equivalently changed Reactome pathways in the antidepressant data

From: Equivalent change enrichment analysis: assessing equivalent and inverse change in biological pathways between diverse experiments

PathwayFDRNESSizeTop 5 Genes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)2.76 × 10−21.3878Gpc3,Trf,Scg3,Penk,F5
Post-translational protein phosphorylation3.02 × 10−21.3873Gpc3,Trf,Scg3,Penk,F5
GPCR ligand binding1.14 × 10−11.22200Mc3r,Sstr5,Crhr2,Glp1r,Nts
L13a-mediated translational silencing of Ceruloplasmin expression8.07 × 10−31.39100Rpsa,Rpl34,Rplp1,Rps29,Rpl8
Eukaryotic Translation Initiation8.07 × 10− 31.35108Rpsa,Rpl34,Rplp1,Rps29,Rpl8
Formation of a pool of free 40S subunits8.07 × 10−31.4590Rpsa,Rpl34,Rplp1,Rps29,Rpl8
GTP hydrolysis and joining of the 60S ribosomal subunit1.48 × 10−21.38101Rpsa,Rpl34,Rplp1,Rps29,Rpl8
Cap-dependent Translation Initiation8.07 × 10−31.35108Rpsa,Rpl34,Rplp1,Rps29,Rpl8
Translation3.02 × 10−21.23211Mrpl10,Mrps16,Rpsa,Rpl34,Rplp1
SRP-dependent cotranslational protein targeting to membrane8.07 × 10−31.5381Rpsa,Rpl34,Rplp1,Rps29,Rpl8
Major pathway of rRNA processing in the nucleolus and cytosol8.07 × 10−31.36156Exosc10,Rpsa,Rpl34,Rplp1,Rps29
rRNA processing8.07 × 10−31.36156Exosc10,Rpsa,Rpl34,Rplp1,Rps29
rRNA processing in the nucleus and cytosol8.07 × 10−31.36156Exosc10,Rpsa,Rpl34,Rplp1,Rps29
Nonsense-Mediated Decay (NMD)8.07 × 10−31.44102Upf2,Rpsa,Rpl34,Rplp1,Rps29
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)8.07 × 10−31.5183Rpsa,Rpl34,Rplp1,Rps29,Rpl8
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)8.07 × 10−31.44102Upf2,Rpsa,Rpl34,Rplp1,Rps29
Sulfur amino acid metabolism8.07 × 10−31.7419Slc25a10,Gm4737,Ahcy,Cdo1,Adi1