Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication

BMC Genomics

Table 1 KEGG_ pathways enriched among different types of variants

Type of variants	KEGG_ pathways ID	Description	Animal	P-value (wolf)	P-value (dog)
Small indels	hsa05200	Pathways in cancer	Both	0.0020	0.0010
Small indels	hsa05218	Melanoma	Both	0.0487	0.0405
translocation	hsa04740	Olfactory transduction	Both	0.0005	0.0016
Structural variant (translocation)	hsa04612	Antigen processing and presentation	Both	0.0004	0.0385
Structural variant (translocation)	hsa01200	Carbon metabolism	Dog	–	0.0996
Structural variant (inversion)	hsa04973	Carbohydrate digestion and absorption	Dog	–	0.0613
Structural variant (inversion)	hsa04970	Salivary secretion	Dog	–	0.0804
Structural variant (indels)	hsa04662:	B cell receptor signaling pathway	Both	0.0085	0.0165
Structural variant (indels)	hsa04660:	T cell receptor signaling pathway	Both	0.0163	0.0655
CNV	hsa04740	Olfactory transduction		4.04E-15	0.0957
CNV	hsa04260	Cardiac muscle contraction	Dog^a	–	0.0667
CNV	hsa00500	Starch and sucrose metabolism	Dog		0.0119
CNV	hsa04020	Calcium signaling pathway	Both	0.0775	0.0238
CNV	hsa00140	Steroid hormone biosynthesis	Both	0.0385	0.0802

ISSN: 1471-2164