Table 2 Top 20 significant genes in the CON and PRO group sorted on level of significance (F-test q-value< 0.0001) in the CON (A) and PRO (B) group. Q-values for CON and PRO group as well as the interaction effect of endurance exercise training with protein supplementation are adjusted IMBT p-values. FC is the signed fold change. CON is the change in the control group. PRO is the change in the protein group. Inter is the interaction effect between protein supplementation and endurance training
(A). Gene | FC CON | FC PRO | Q-val. CON | Q-val. PRO | P-val. Inter | Q-val. Inter |
|---|---|---|---|---|---|---|
LAMA4 | 1.39 | 1.57 | 0.000 | 0.000 | 0.051 | 0.821 |
COL4A1 | 1.69 | 1.87 | 0.000 | 0.000 | 0.311 | 0.933 |
A2M | 1.22 | 1.33 | 0.000 | 0.000 | 0.029 | 0.796 |
MYO1B | 1.37 | 1.44 | 0.000 | 0.000 | 0.476 | 0.957 |
CD34 | 1.28 | 1.33 | 0.000 | 0.000 | 0.496 | 0.958 |
NFIX | −1.12 | −1.09 | 0.000 | 0.001 | 0.288 | 0.926 |
THBS4 | 1.61 | 1.94 | 0.000 | 0.000 | 0.081 | 0.853 |
COL4A2 | 1.54 | 1.77 | 0.000 | 0.000 | 0.144 | 0.881 |
RYR3 | 1.42 | 1.12 | 0.000 | 0.336 | 0.003 | 0.647 |
FXYD1 | −1.15 | −1.13 | 0.000 | 0.000 | 0.612 | 0.974 |
COX4I1 | 1.19 | 1.15 | 0.000 | 0.001 | 0.441 | 0.952 |
TMEM159 | −1.41 | −1.23 | 0.000 | 0.026 | 0.083 | 0.854 |
SMTNL1 | −1.55 | − 1.39 | 0.000 | 0.003 | 0.298 | 0.929 |
LAMB1 | 1.46 | 1.79 | 0.000 | 0.000 | 0.025 | 0.782 |
ALDH1B1 | 1.35 | 1.25 | 0.000 | 0.005 | 0.254 | 0.916 |
RHOJ | 1.32 | 1.15 | 0.000 | 0.090 | 0.035 | 0.799 |
SMOC2 | 1.31 | 1.37 | 0.000 | 0.000 | 0.482 | 0.958 |
LXN | 1.41 | 1.28 | 0.000 | 0.007 | 0.254 | 0.916 |
ANKRD29 | 1.42 | 1.16 | 0.000 | 0.198 | 0.020 | 0.756 |
DECR1 | 1.19 | 1.17 | 0.000 | 0.000 | 0.767 | 0.989 |
(B). Gene | FC PRO | FC CON | Q-val. CON | Q-val. PRO | P-val. Inter | Q-val. Inter |
LAMA4 | 1.57 | 1.39 | 0.000 | 0.000 | 0.051 | 0.821 |
A2M | 1.33 | 1.22 | 0.000 | 0.000 | 0.029 | 0.796 |
LAMB1 | 1.79 | 1.46 | 0.000 | 0.000 | 0.025 | 0.782 |
COL4A1 | 1.87 | 1.69 | 0.000 | 0.000 | 0.311 | 0.933 |
THBS4 | 1.94 | 1.61 | 0.000 | 0.000 | 0.081 | 0.853 |
COL4A2 | 1.77 | 1.54 | 0.000 | 0.000 | 0.144 | 0.881 |
MYO1B | 1.44 | 1.37 | 0.000 | 0.000 | 0.476 | 0.957 |
NID1 | 1.48 | 1.26 | 0.002 | 0.000 | 0.022 | 0.756 |
CD34 | 1.33 | 1.28 | 0.000 | 0.000 | 0.496 | 0.958 |
SPARC | 1.45 | 1.29 | 0.000 | 0.000 | 0.075 | 0.848 |
COL15A1 | 1.43 | 1.25 | 0.001 | 0.000 | 0.045 | 0.816 |
UTRN | 1.22 | 1.12 | 0.003 | 0.000 | 0.029 | 0.796 |
EDNRB | 1.70 | 1.34 | 0.005 | 0.000 | 0.016 | 0.756 |
PXDN | 1.75 | 1.48 | 0.000 | 0.000 | 0.107 | 0.863 |
ETS1 | 1.43 | 1.26 | 0.001 | 0.000 | 0.063 | 0.839 |
MXRA5 | 2.51 | 1.90 | 0.000 | 0.000 | 0.110 | 0.863 |
COL3A1 | 2.06 | 1.70 | 0.000 | 0.000 | 0.178 | 0.893 |
IGFBP7 | 1.35 | 1.26 | 0.000 | 0.000 | 0.233 | 0.914 |
ANXA5 | 1.35 | 1.10 | 0.268 | 0.000 | 0.001 | 0.558 |
CAPN6 | 1.83 | 1.46 | 0.003 | 0.000 | 0.060 | 0.836 |