Fig. 7From: Discovering candidate imprinted genes and imprinting control regions in the human genomeAn intergenic candidate ICR regulating parent-of-origin specific expression of PPP1R14C and IYD. GWAS identified several potentially significant SNPs in PPP1R14C. Thyroid dyshormonogenesis-4 (TDH4) is caused by homozygous mutations in IYD. Patients with this defect lack the ability to deiodinate radiolabeled monoiodotyrosine and diiodotyrosine [40]Back to article page