Table 5 The top 10 immune-related KEGG pathways with the highest enrichment of DEGs in groups with different immune challenges
Pathway ID | DEGs annotation in the pathway | All genes annotation in the pathway | P-values | Pathway annotation |
|---|---|---|---|---|
CT-vs-LPS | ||||
 ko04658 | 21 (1.71%) | 218 (1.43%) | 0.2218435 | Th1 and Th2 cell differentiation |
 ko04670 | 20 (1.63%) | 208 (1.36%) | 0.2311792 | Leukocyte transendothelial migration |
 ko04650 | 11 (0.9%) | 115 (0.75%) | 0.3179508 | Natural killer cell mediated cytotoxicity |
 ko04666 | 14 (1.14%) | 155 (1.01%) | 0.3636409 | Fc gamma R-mediated phagocytosis |
 ko04659 | 8 (0.65%) | 88 (0.58%) | 0.4117395 | Th17 cell differentiation |
 ko05340 | 4 (0.33%) | 42 (0.27%) | 0.4392712 | Primary immunodeficiency |
 ko04623 | 9 (0.73%) | 105 (0.69%) | 0.4703544 | Cytosolic DNA-sensing pathway |
 ko04640 | 4 (0.33%) | 46 (0.3%) | 0.5109961 | Hematopoietic cell lineage |
 ko04664 | 8 (0.65%) | 98 (0.64%) | 0.5344647 | Fc epsilon RI signaling pathway |
 ko04672 | 2 (0.16%) | 23 (0.15%) | 0.561599 | Intestinal immune network for IgA production |
CT-vs-PIC | ||||
 ko04672 | 6 (0.4%) | 23 (0.15%) | 0.02188151 | Intestinal immune network for IgA production |
 ko04670 | 28 (1.84%) | 208 (1.36%) | 0.05993948 | Leukocyte transendothelial migration |
 ko04650 | 17 (1.12%) | 115 (0.75%) | 0.06204072 | Natural killer cell mediated cytotoxicity |
 ko04666 | 21 (1.38%) | 155 (1.01%) | 0.08842557 | Fc gamma R-mediated phagocytosis |
 ko04664 | 13 (0.86%) | 98 (0.64%) | 0.1727241 | Fc epsilon RI signaling pathway |
 ko04623 | 13 (0.86%) | 105 (0.69%) | 0.2419115 | Cytosolic DNA-sensing pathway |
 ko04640 | 6 (0.4%) | 46 (0.3%) | 0.3049254 | Hematopoietic cell lineage |
 ko04662 | 12 (0.79%) | 102 (0.67%) | 0.312857 | B cell receptor signaling pathway |
 ko04620 | 13 (0.86%) | 118 (0.77%) | 0.3906605 | Toll-like receptor signaling pathway |
 ko05340 | 5 (0.33%) | 42 (0.27%) | 0.4066475 | Primary immunodeficiency |
CT-vs-VH | ||||
 ko04666 | 17 (1.65%) | 155 (1.01%) | 0.03195124 | Fc gamma R-mediated phagocytosis |
 ko04062 | 18 (1.75%) | 188 (1.23%) | 0.08324536 | Chemokine signaling pathway |
 ko05340 | 5 (0.49%) | 42 (0.27%) | 0.1499922 | Primary immunodeficiency |
 ko04650 | 11 (1.07%) | 115 (0.75%) | 0.1515229 | Natural killer cell mediated cytotoxicity |
 ko04672 | 3 (0.29%) | 23 (0.15%) | 0.1992882 | Intestinal immune network for IgA production |
 ko04664 | 9 (0.87%) | 98 (0.64%) | 0.2139022 | Fc epsilon RI signaling pathway |
 ko04659 | 8 (0.78%) | 88 (0.58%) | 0.2403939 | Th17 cell differentiation |
 ko05321 | 2 (0.19%) | 14 (0.09%) | 0.2423557 | Inflammatory bowel disease (IBD) |
 ko04662 | 9 (0.87%) | 102 (0.67%) | 0.2484696 | B cell receptor signaling pathway |
 ko04623 | 9 (0.87%) | 105 (0.69%) | 0.2755423 | Cytosolic DNA-sensing pathway |