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Table 5 The top 10 immune-related KEGG pathways with the highest enrichment of DEGs in groups with different immune challenges

From: Transcriptomic analysis of sea cucumber (Holothuria leucospilota) coelomocytes revealed the echinoderm cytokine response during immune challenge

Pathway IDDEGs annotation in the pathwayAll genes annotation in the pathwayP-valuesPathway annotation
CT-vs-LPS
ko0465821 (1.71%)218 (1.43%)0.2218435Th1 and Th2 cell differentiation
ko0467020 (1.63%)208 (1.36%)0.2311792Leukocyte transendothelial migration
ko0465011 (0.9%)115 (0.75%)0.3179508Natural killer cell mediated cytotoxicity
ko0466614 (1.14%)155 (1.01%)0.3636409Fc gamma R-mediated phagocytosis
ko046598 (0.65%)88 (0.58%)0.4117395Th17 cell differentiation
ko053404 (0.33%)42 (0.27%)0.4392712Primary immunodeficiency
ko046239 (0.73%)105 (0.69%)0.4703544Cytosolic DNA-sensing pathway
ko046404 (0.33%)46 (0.3%)0.5109961Hematopoietic cell lineage
ko046648 (0.65%)98 (0.64%)0.5344647Fc epsilon RI signaling pathway
ko046722 (0.16%)23 (0.15%)0.561599Intestinal immune network for IgA production
CT-vs-PIC
ko046726 (0.4%)23 (0.15%)0.02188151Intestinal immune network for IgA production
ko0467028 (1.84%)208 (1.36%)0.05993948Leukocyte transendothelial migration
ko0465017 (1.12%)115 (0.75%)0.06204072Natural killer cell mediated cytotoxicity
ko0466621 (1.38%)155 (1.01%)0.08842557Fc gamma R-mediated phagocytosis
ko0466413 (0.86%)98 (0.64%)0.1727241Fc epsilon RI signaling pathway
ko0462313 (0.86%)105 (0.69%)0.2419115Cytosolic DNA-sensing pathway
ko046406 (0.4%)46 (0.3%)0.3049254Hematopoietic cell lineage
ko0466212 (0.79%)102 (0.67%)0.312857B cell receptor signaling pathway
ko0462013 (0.86%)118 (0.77%)0.3906605Toll-like receptor signaling pathway
ko053405 (0.33%)42 (0.27%)0.4066475Primary immunodeficiency
CT-vs-VH
ko0466617 (1.65%)155 (1.01%)0.03195124Fc gamma R-mediated phagocytosis
ko0406218 (1.75%)188 (1.23%)0.08324536Chemokine signaling pathway
ko053405 (0.49%)42 (0.27%)0.1499922Primary immunodeficiency
ko0465011 (1.07%)115 (0.75%)0.1515229Natural killer cell mediated cytotoxicity
ko046723 (0.29%)23 (0.15%)0.1992882Intestinal immune network for IgA production
ko046649 (0.87%)98 (0.64%)0.2139022Fc epsilon RI signaling pathway
ko046598 (0.78%)88 (0.58%)0.2403939Th17 cell differentiation
ko053212 (0.19%)14 (0.09%)0.2423557Inflammatory bowel disease (IBD)
ko046629 (0.87%)102 (0.67%)0.2484696B cell receptor signaling pathway
ko046239 (0.87%)105 (0.69%)0.2755423Cytosolic DNA-sensing pathway