Fig. 3
From: Modern human changes in regulatory regions implicated in cortical development
Progenitor cell-fate decisions shaped by WNT/β-CATENIN signaling. Based on studies in mice, it is hypothesized that early during neurodevelopment, WNT/β-CATENIN signaling promotes neural stem and progenitor cell self-renewal whereas its depletion causes premature neuronal differentiation [45,46,47]; later on, its down-regulation is required for generation of intermediate progenitor cells from radial glial cells [47, 48]. Lastly, WNT/β-CATENIN signaling promotes differentiation of intermediate progenitors to produce neurons [46]