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Table 4 Heterozygous mutations in genes involved in DNA repair

From: Genomic analysis of a riboflavin-overproducing Ashbya gossypii mutant isolated by disparity mutagenesis

Chromosome

Position

WT seq.

MT seq

Quality

Mutation

Gene

Product

DNA changes

Protein changes

Read number

MT seq ratio

WT seq.

MT seq.

I

177,825

G

T

533.19

missense

AGOS_AAL093C

DNA mismatch repair protein (AgMLH3)

c.1516C > A

p.L506M

22

17

0.436

IV

997,942

T

G

729.19

missense

AGOS_ADR168C

DNA mismatch repair protein (AgMSH3)

c.2937A > C

p.K979N

39

23

0.371

IV

998,607

G

A

982.19

nonsense

AGOS_ADR168C

DNA mismatch repair protein (AgMSH3)

c.2272C > T

p.Q758*

22

29

0.569

IV

1,446,658

G

T

747.19

missense

AGOS_ADR411W

Checkpoint protein (AgRAD17)

c.358G > T

p.D120Y

32

24

0.429

V

486,710

G

A

711.19

missense

AGOS_AEL075W

DNA polymerase delta subunit 3 (AgPOL32)

c.490G > A

p.A164T

18

22

0.550

V

1,239,357

C

A

411.19

missense

AGOS_AER327C

Uracil-DNA glycosylase (AgUNG1)

c.757G > T

p.A253S

27

16

0.372

V

1,445,972

G

A

869.19

missense

AGOS_AER421W

DNA mismatch repair protein (AgPMS1)

c.1762G > A

p.A588T

23

28

0.549

VI

65,368

C

T

587.19

missense

AGOS_AFL199C

DNA mismatch repair protein (AgMLH1)

c.320G > A

p.C107Y

20

20

0.500

VI

677,447

G

A

967.19

nonsense

AGOS_AFR133C

single-stranded DNA endonuclease (AgRAD2)

c.2143C > T

p.Q715*

25

30

0.545

VI

677,525

C

A

743.19

missense

AGOS_AFR133C

single-stranded DNA endonuclease (AgRAD2)

c.2065G > T

p.D689Y

27

28

0.509

VI

834,113

A

G

889.19

missense

AGOS_AFR220W

DNA helicase/Ubiquitin ligase (AgRAD5)

c.2419A > G

p.S807G

18

25

0.581

VI

834,860

G

T

678.19

nonsense

AGOS_AFR220W

DNA helicase/Ubiquitin ligase (AgRAD5)

c.3166G > T

p.E1056*

29

22

0.431

VI

848,262

A

G

828.19

missense

AGOS_AFR226C

DNA mismatch repair protein (AgMLH2)

c.1882 T > C

p.F628L

26

31

0.544

VI

1,528,970

C

T

1142.19

nonsense

AGOS_AFR603C

DNA mismatch repair protein (AgMSH2)

c.2711G > A

p.W904*

18

36

0.667

VI

1,529,553

G

A

1151.19

missense

AGOS_AFR603C

DNA mismatch repair protein (AgMSH2)

c.2128C > T

p.P710S

12

33

0.733

VII

1,278,725

T

G

786.19

missense

AGOS_AGR116W

DNA mismatch repair protein (AgMSH6)

c.1005 T > G

p.N335K

24

25

0.510

VII

1,368,167

C

T

788.19

missense

AGOS_AGR162C

DNA repair protein (AgRAD4)

c.1214G > A

p.R405Q

17

23

0.575

  1. *Translation stops here
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