Fig. 6

Gene set enrichment analysis (GSEA). GSEA was performed in the HRFI and LRFI groups. The GSEA algorithm calculates an enrichment score reflecting the degree of overrepresentation at the top or bottom of the ranked list of the genes included in a gene set in a ranked list of all genes present in the RNA-seq dataset. A positive enrichment score (ES) indicates gene set enrichment at the top of the ranked list; a negative ES indicates gene set enrichment at the bottom of the ranked list. The analysis demonstrates that known (a) Mitochondrial membrane part and (b) Electron transport chain, are enriched in LRFI groups, while (c) Negative regulation of cytokine-mediated signaling pathway and (d) Negative regulation of response to cytokine stimulus are enriched in HRFI groups