Fig. 4

Reliability of ICGEC. a Correlation of gene scores between the use of the full data and the leave-one-mark-out data. The labels on the x-axis indicate the individual marks to be removed during ICGEC calculation. b Heatmap showing the mark scores obtained with the full data and the leave-one-mark-out data. Each colored cell indicates the mark score of a specific mark (y-axis) produced from datasets with either all marks (“full”) or all but one mark (x-axis). c Barplot showing the number of DEGs (blue) and essential genes (gray) included in the gene sets with different levels of epigenetic conservation. The 20 gene sets from left to right presented the lowest to highest gene scores. Genes were classified into bins with proximately equal sizes according to their gene scores. d Number of DEGs in the most epigenetically dynamic gene set versus the composition of the mark sets. The labels on the x-axis indicate that either all marks or all but one specific mark were used by ICGEC