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Table 1 SNPs demonstrating significant association to CHD in the across-breed CMH test for stratified data

From: An across-breed validation study of 46 genetic markers in canine hip dysplasia

SNP Location in CanFam3.1 Allele (minor / major) Raw P-value (PRAW) Permuted P-value (PGEN) OR (95% CI) Origins of the SNP (study, breeds, and phenotypes)
ss7212922120 CFA1: 45382633 A/C 7.4 × 10–03 8.4 × 10–03 1.30 [1.07–1.57] Mikkola et al. (2019) [13]/ German Shepherd / FCI hip score
ss7212922135 CFA14: 56572744 T/C 0.027 0.028 1.19 [1.02–1.38] Pfahler & Distl (2012) [6]/ Bernese Mountain dog / FCI hip score
ss7212922151 CFA26: 14157064 T/C 8.8 × 10–03 0.011 1.26 [1.06–1.49] Fels & Distl (2014) [7]/ German Shepherd/ FCI hip score
ss7212922139 CFA37: 14299531 C/A 0.030 0.032 0.84 [0.72–0.98] Zhou et al. (2010) [4]/ Multiple breeds and breed crosses/ OA
  1. CI confidence interval; OR odds ratio. The odds ratios and their 95% confidence intervals were calculated by PLINK using default settings in which the minor allele increases the risk when OR > 1. The reference genome used in this study is CanFam3.1