Table 1 Identification of differentially expressed gene based on transcriptome sequencing

Phosphatidate phosphatase LPIN1

43.18282

386.1148

3.160501

Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, mTOR signaling pathway.

Generating 1,2-Diacyl-sn-glycerol

3-keto-steroid reductase-like

1.127324

20.46541

4.182214

Steroid biosynthesis, Steroid hormone biosynthesis, Metabolic pathways.

Generating 4alpha-methylzymosterol or Hydroxyestrone

general transcription factor IIF subunit 2 isoform X2

1.302917

25.49286

4.290276

Basal transcription factors.

Transcription

sterol-4alpha-carboxylate 3-dehydrogenase

10.80255

140.7436

3.703626

Steroid biosynthesis, Metabolic pathways.

Generating 3-Keto-4-methylzymosterol

endothelial lipase

72.61555

753.4305

3.375124

Glycerolipid metabolism, Metabolic pathways.

Generating fatty acid

serum/glucocorticoid-regulated kinase 1

1.328233

33.50641

4.656857

mRNA surveillance pathway, cAMP signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Hippo signaling pathway, Focal adhesion, Platelet activation, Long-term potentiation, Dopaminergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Oxytocin signaling pathway.

ATP-binding cassette, subfamily C (CFTR/MRP), member 12

1.067294

25.75915

4.593055

ABC transporters.

stearoyl-CoA desaturase

863.601

10,415.86

3.592273

Biosynthesis of unsaturated fatty acids, Fatty acid metabolism, PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway – worm.

Fatty acid desaturation

PH domain and leucine-rich repeat-containing protein phosphatase

4.106606

53.87121

3.713496

hospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse

Retinol dehydrogenase 12

7.270524

99.28454

3.771438

Retinol metabolism, Metabolic pathways

Generating all-trans-Retinal

lymphokine-activated killer T-cell-originated protein kinase homolog

6.070951

145.7947

4.585872

Pancreatic secretion, Protein digestion and absorption

5-phosphohydroxy-L-lysine phospho-lyase

1.974891

34.93728

4.144922

Lysine degradation, Metabolic pathways

Generating Allysine

transcription factor CP2-like protein 1

33.3349

1.088583

−4.93651

serum/glucocorticoid regulated kinase 1

87.45664

1.841215

−5.56984

FoxO signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Aldosterone-regulated sodium reabsorption

hypoxia up-regulated 1

135.8593

1.88101

−6.17446

Protein processing in endoplasmic reticulum

Alcohol dehydrogenase [NADP(+)] A

550.9179

101.9587

−2.43385

Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Glycerolipid metabolism, Metabolic pathways

Generating glucuronate, ethanal or D-Glyceraldehyde

Phosphatidate phosphatase LPIN1

230.0628

21.91613

−3.39196

Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, mTOR signaling pathway

Copper-transporting ATPase 2

923.8284

210.7988

−2.13176

Mineral absorption

calcium/calmodulin-dependent serine protein kinase

55.2038

1.86159

−4.89016

Tight junction

solute carrier family 2, facilitated glucose transporter member 5

16.81712

0.94255

−4.15722

Carbohydrate digestion and absorption

Froctose or glucose absorption

phosphoglycolate phosphatase

15.43525

0.934372

−4.04609

Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism

Generating glycolate

Nuclear receptor coactivator 7

31.91563

1.559127

−4.35545

RNA degradation

Plasma kallikrein

20,520.24

418.6751

−5.61507

Complement and coagulation cascades

complement component 2

2119.225

73.06701

−4.85817

Complement and coagulation cascades,