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Table 2 Secreted proteins shared between P. wickerhamii and either C. albicans or T. rubrum

From: A first insight into the genome of Prototheca wickerhamii, a major causative agent of human protothecosis

No.

C. albicans

T. rubrum

Interpro (IPR) function

Ortha

Gene

Ortha

Gene

1.

1

CAALFM_CR00690CA; Uncharacterized protein

1

TERG_00664; Uncharacterized protein

Kinase

2.

0

–

1

TERG_04330; Uncharacterized protein

Folding of proteins in the endoplasmic reticulum

3.

0

–

1

TERG_01168; Uncharacterized protein

Involved in vacuolar sorting

4.

0

–

1

TERG_03290; Uncharacterized protein

Involved in nuclear export

5.

1

APR1, Proteinase A

1

TERG_06704; Vacuolar protease A

Involved in lipid metabolism/virulence

6.

1

GUT2; Glycerol-3-phosphate dehydrogenase

1

TERG_12172; Uncharacterized protein

Oxidoreductase activity

7.

1

PEP1; Sortilin

1

TERG_02098; Sortilin

Involved in vacuolar protein sorting

8.

1

PNC1; Nicotinamidase

1

TERG_06866; Uncharacterized protein

Catalytic activity/hydrolase

9.

1

CAALFM_CR00660WA; Uncharacterized protein

0

–

Proteolysis/virulence

10.

0

–

1

TERG_00899; Neutral ceramidase

Hydrolyses ceramide to generate sphingosine and fatty acid

11.

1

PDI1; Protein disulfide isomerase

1

TERG_04662; Protein disulfide-isomerase

Isomerase activity

12.

1

ROT2; Glucan 1\3-alpha-glucosidase

1

TERG_04559; Uncharacterized protein

Glycoside hydrolase

13.

1

SKN1; Skn1p

1

TERG_03740; Uncharacterized protein

Glycoside hydrolase

14.

1

HEX1; Beta-hexosaminidase

1

TERG_04775; Beta-hexosaminidase

Glycoside hydrolase

15.

1

NCR1; Sphingolipid transporter

1

TERG_02938; Uncharacterized protein

Involved in transport of cholesterol

  1. aExistence of orthologs in P. wickerhamii; 0 – absent; 1 – present