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Table 4 Expression of mTOR pathway-related proteins in liver tissue from 4-d old Holstein calves (n = 6/group) born to cows randomly assigned to receive a basal control (CON) diet from − 28 ± 2 d to parturition [1.47 Mcal/kg dry matter (DM) and 15.3% crude protein (CP)] with no added Met or CON plus ethyl cellulose Met (MET, Mepron®, Evonik Nutrition & Care GmbH, Germany)

From: Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows

Protein (log-transformed data)

Maternal diet

SEM

p-value

CON

MET

Total protein

 mTOR

0.93

0.90

0.08

0.85

 S6K1

2.55

2.38

0.10

0.43

 AKT

2.49

1.48

0.19

<.00

 4EBP1

2.39

2.42

0.17

0.93

 eEF2

1.91

1.69

0.09

0.26

 eIF2a

2.31

2.05

0.08

0.12

 RPS6

2.07

2.33

0.21

0.57

Phosphorylated protein

 p-mTOR

0.62

0.69

0.06

0.59

 p-S6K1

2.61

1.62

0.18

<.00

 p-AKT

2.46

2.24

0.11

0.36

 p-4EBP1

1.50

1.58

0.10

0.72

 p-eEF2

0.98

0.59

0.16

0.25

 p-eIF2a

2.41

2.08

0.15

0.29

 p-RPS6

1.78

1.17

0.21

0.15

Ratio

 p-mTOR/mTOR

0.74

0.85

0.12

0.69

 p-S6K1/S6K1

1.04

0.70

0.07

0.01

 p-AKT/AKT

1.01

1.52

0.09

<.00

 p-4EBP1/4EBP1

0.65

0.71

0.07

0.66

 p-eEF2/eEF2

0.51

0.36

0.08

0.35

 p-eIF2a/eIF2a

1.04

1.01

0.05

0.73

 p-RPS6/RPS6

0.90

0.61

0.13

0.28

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BMC Genomics

ISSN: 1471-2164

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