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Table 7 Abundance of genes related to methionine metabolism, DNA methylation, glutathione metabolism, and cytidine 5′-diphosphocholine (CDP)–choline pathway in liver tissue from 4-d old Holstein calves (n = 6/group) born to cows randomly assigned to receive a basal control (CON) diet from − 28 ± 2 d to parturition [1.47 Mcal/kg dry matter (DM) and 15.3% crude protein (CP)] with no added Met or CON plus ethyl cellulose Met (MET, Mepron®, Evonik Nutrition & Care GmbH, Germany)

From: Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows

Gene (log2 scale) Maternal diet SEM p-value
CON MET
Methionine cycle
MAT1A 0.01 0.03 0.01 0.09
BHMT 1.23 0.98 0.11 0.26
BHMT2 0.06 0.11 0.04 0.33
MTR 0.73 1.04 0.11 0.19
SAHH 0.04 0.10 0.01 0.53
PEMT 0.09 0.17 0.02 0.07
BADH 1.16 1.20 0.06 0.73
CHDH 1.57 1.50 0.15 0.76
SARDH 0.93 0.83 0.06 0.40
DNA methylation
DNMT1 0.95 0.94 0.03 0.93
DNMT3A 0.97 0.88 0.05 0.36
Transsulfuration
CBS 0.76 0.73 0.05 0.81
CDO1 0.91 0.74 0.05 0.08
CSAD 0.34 0.30 0.02 0.37
CTH 1.18 1.45 0.09 0.20
Glutathione pathway
GSS 1.02 0.97 0.03 0.48
GCLC 0.50 0.52 0.06 0.95
GSR 0.61 0.70 0.04 0.27
GPX1 0.86 1.02 0.06 0.13
CDP–choline pathway
CHKA 0.75 0.96 0.10 0.31
CHKB 0.76 0.76 0.03 0.94
PCYT1A 0.94 0.98 0.05 0.66
PCYT1B 0.82 0.50 0.08 0.04
CEPT1 0.94 0.96 0.05 0.92