Fig. 2

Average nucleotide identity (ANI)-based species boundaries and phylogenetic distribution of biosynthetic gene clusters (BGCs). Species boundaries are delineated using alternating light gray and dark gray boxes and were defined based on the 95% ANI threshold. Three sub-clusters that can be considered as distinct species based on the ANI threshold are tentatively labeled as species 20, 29 and 38. Acronyms: AT – acyltransferase; CDPS – tRNA-dependent cyclodipeptide synthases; hgIE-KS – heterocyst glycolipid synthase-like ketide synthase; NRPS – non-ribosomal peptide synthetase; PKS – polyketide synthase