Fig. 3

Predicted sensitivity of tumor-types and normal tissue to trametinib. a, Violin plots of predicted ln (IC₅₀) values of trametinib based on RNA-seq gene expression data from TCGA tumor samples from 33 tumor types. Overall COAD, READ, SKCM and UVM tumors (yellow) had the lowest predicted median IC₅₀ values. For the description of the 33 TCGA tumor types, see supplementary data (additional file 1: Table S7A). The solid line shows the median of the medians of the predicted IC₅₀ values for all 33 tumor types whereas the dashed line is one logarithmic unit below the solid line. b, Violin plots of the predicted ln (IC₅₀) values of trametinib for COAD tumor (red) and normal (blue) samples from TCGA and for GTEx normal tissue samples from 15 major organs (green); here the solid line shows the median of the medians of the predicted IC₅₀ values for all 16 normal tissues. In each violin, the red dot is located at the median; the vertical red bar extends from 25th to 75th percentiles