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Table 2 Drugs to which breast cancer subtype(s) in TCGA samples were predicted to be sensitive. The lowest predicted ln (IC50) values among the subtypes are in bold

From: Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines

Drug Median Predicted ln (IC50) value (Number of samples)
ID Name Target Basal-like (191) Her2-pos (82) Luminal A (567) Luminal B (219) Normal-like (41)
1378 Bleomycin DNA 2.482 3.225 3.186 3.371 2.775
1248 Daporinad NAMPT −2.439 −1.441 −1.665 −1.768 −1.864
268 Sepantronium br. BIRC5 −3.622 −3.388 −2.824 − 3.040 − 2.957
134 Etoposide TOP2 1.734 2.344 2.403 2.369 2.073
1266 ICL1100013 NMT1 2.443 3.032 2.988 3.064 2.822
1910 ABT737 BCL2 2.037 2.176 1.500 1.401 1.940
1011 Navitoclax BCL2 1.873 1.951 1.357 1.188 1.693
1594 OSI-027 mTOR 2.928 2.444 2.829 2.748 2.842