Table 4 Gene annotation according to DAVID Database (Functional Annotation Clustering tool) (P-Value < 0.10). Species used as genetic background: Bos taurus; list uploaded = n.409 genes; genes recognized = n.334). Bold = P-value < 0.05
From: A genome-wide scan of copy number variants in three Iranian indigenous river buffaloes
Category | Term | N | P-value | Genes |
|---|---|---|---|---|
Biological Process | GO:0000381 ~ regulation of alternative mRNA splicing, via spliceosome | 5 | 3.47E-03 | RBFOX1, MYOD1, MAGOH, RBM11, SRSF12 |
GO:0042060 ~ wound healing | 5 | 3.85E-03 | SLC11A1, TFF3, TFF2, MIA3, TFF1 | |
GO:0006811 ~ ion transport | 4 | 6.04E-03 | CLDN10, SLC11A1, SLCO2B1, CLDN16 | |
GO:0032691 ~ negative regulation of interleukin-1 beta production | 3 | 6.39E-03 | GHSR, ACP5, TNFAIP3 | |
GO:0030163 ~ protein catabolic process | 5 | 7.31E-03 | PAG8, PAG18, PAG17, PAG19, PAG16 | |
GO:0050885 ~ neuromuscular process controlling balance | 5 | 8.58E-03 | RBFOX1, JPH3, CAMTA1, ATP2B2, NBN | |
GO:0021952 ~ central nervous system projection neuron axonogenesis | 3 | 1.07E-02 | SPTBN4, EPHB1, EPHB3 | |
GO:0007605 ~ sensory perception of sound | 6 | 2.42E-02 | SPTBN4, CNTN5, TMPRSS3, SLC52A3, OTOG, USH1C | |
GO:0070328 ~ triglyceride homeostasis | 3 | 3.28E-02 | SCARB1, HNF4A, ANGPTL8 | |
GO:0006508 ~ proteolysis | 8 | 3.93E-02 | CAPN14, DPP6, CPXM2, PAG8, PAG18, PAG17, PAG19, PAG16 | |
GO:0018108 ~ peptidyl-tyrosine phosphorylation | 3 | 4.52E-02 | RIPK2, MAP 2 K6, IGF1R | |
GO:0021915 ~ neural tube development | 3 | 5.42E-02 | NUP133, INTU, PLXNA2 | |
GO:0051480 ~ regulation of cytosolic calcium ion concentration | 3 | 5.89E-02 | CALB1, ATP2B2, TMEM64 | |
GO:0032465 ~ regulation of cytokinesis | 3 | 5.89E-02 | UVRAG, KLHL21, BIRC6 | |
GO:0006915 ~ apoptotic process | 8 | 7.69E-02 | KANK2, PEG3, C1H3ORF38, RIPK2, JADE1, ARRB1, BIRC6, MAP 2 K6 | |
GO:0007586 ~ digestion | 3 | 7.92E-02 | TFF3, TFF2, TFF1 | |
GO:0010508 ~ positive regulation of autophagy | 3 | 7.92E-02 | UVRAG, TRIM65, TRIM21 | |
Cellular Compounent | GO:0005737 ~ cytoplasm | 64 | 6.17E-02 | DOCK6, JADE1, TNFAIP3, ARRB1, ECSIT, IGF1R, ARHGAP44, MAP 1LC3B, CATIP, HNF4A, MAGOH, GDAP1L1, PRX, TRIM21, RBFOX1, PEG3, RIPK2, CLDN10, ACTA1, BIN1, EIF4E1B, RUFY3, RNF207, SHPK, TFF3, TAX1BP3, DNAJC9, BIRC6, ARHGEF5, SNRPA, KANK2, NUMBL, WDR26, INTU, ZBTB48, USH1C, NEDD4L, GLRX, EVPL, STK3, UBE2J1, PDLIM1, NEU3, PDZD2, FGGY, SERTAD1, HECTD2, TRIM47, SPOCK1, CAMTA1, MAP 4 K5, MAP 2 K6, HIPK4, ECD, LIMK1, KLHL21, HTR1B, ELL2, WAPL, CAPN14, SPSB1, PPP1R1C, SERGEF, GALK1 |
GO:0043005 ~ neuron projection | 6 | 6.94E-02 | SLC4A8, GHSR, CALB1, LIMK1, SLC17A6, SLC6A11 | |
GO:0000139 ~ Golgi membrane | 8 | 7.51E-02 | GALNT6, SEC16B, EXT2, GOLPH3, GALNT14, MAN1A1, MIA3, GALNTL6 | |
GO:0005578 ~ proteinaceous extracellular matrix | 7 | 8.27E-02 | OLFML2B, ENAM, COL22A1, TFF3, LTBP4, COL6A3, SPOCK1 | |
Molecular Function | GO:0004190 ~ aspartic-type endopeptidase activity | 5 | 5.14E-03 | PAG8, PAG18, PAG17, PAG19, PAG16 |
GO:0005524 ~ ATP binding | 30 | 4.47E-02 | ATP6V1A, NVL, RHOBTB3, NOL9, IGF1R, STK3, HK3, AKT2, FYN, MAP 4 K5, EPHB1, GLUL, EPHB3, MAP 2 K6, HIPK4, ABCC4, RIPK2, RFC2, ABCC8, INSR, LIMK1, ATP2B2, CIT, ACTA1, BBS10, CDK3, ROR1, ABCG1, GALK1, CDKL1 | |
GO:0016874 ~ ligase activity | 5 | 7.75E-02 | MCCC2, HECTD2, NEDD4L, TRIM21, GLUL | |
GO:0001105 ~ RNA polymerase II transcription coactivator activity | 3 | 8.75E-02 | MYOCD, WBP2, JADE1 | |
KEGG | bta04360:Axon guidance | 8 | 2.61E-03 | EPHA6, UNC5A, DCC, LIMK1, PLXNA2, FYN, EPHB1, EPHB3 |
bta04024:cAMP signaling pathway | 7 | 7.61E-02 | GHSR, HTR1F, ACOX1, AKT2, ARAP3, HTR1B, ATP2B2 | |
bta04520:Adherens junction | 4 | 8.14E-02 | INSR, FYN, SORBS1, IGF1R | |
bta00512:Mucin type O-Glycan biosynthesis | 3 | 8.24E-02 | GALNT6, GALNT14, GALNTL6 |