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Fig. 2 | BMC Genomics

Fig. 2

From: Transcriptomics analysis of differentially expressed genes in subcutaneous and perirenal adipose tissue of sheep as affected by their pre- and early postnatal malnutrition histories

Fig. 2

Venn diagram showing the number of top 10 ranked genes and hub genes. The hub genes were identified (genes overlapped in the four centrality methods) in the following comparisons: a LOW vs HIGH, b LOW vs NORM, c interaction between prenatal nutrition and sex (PreNxsex), d LOW-HCHF vs NORM-CONV, e HIGH-HCHF vs NORM-CONV, and f HCHF vs CONV. For the selection of hub genes, the PPI networks were first constructed using the DEGs with a high-confidence score < 0.70, followed by selection of top 10 ranked DEGs based on four centrality methods: Degree, EcCentrity, EPC, and MNC performed in the CytoHubba application (Cytoscape-plug in). Finally, genes that fell within all of these four criteria were considered as hub genes

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BMC Genomics

ISSN: 1471-2164

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