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Table 2 The top 10 known up- and downregulated DEGs for the six (A-F) group comparisons

From: Transcriptomics analysis of differentially expressed genes in subcutaneous and perirenal adipose tissue of sheep as affected by their pre- and early postnatal malnutrition histories

Gene symbol

Log2FC

P-value

padj

Encoded protein

Expression

A) LOW vs HIGH

 DSCAM

−5.460

2.84E-05

0.015

Down Syndrome Cell Adhesion Molecule

down

 C10orf71

−5.395

7.26E-07

0.006

Chromosome 10 Open Reading Frame 71

down

 TMEM63C

−5.120

1.42E-05

0.015

Transmembrane Protein 63C

down

 FAM221A

−4.924

6.54E-05

0.015

Family With Sequence Similarity 221 Member A

down

 ADAM7

−4.889

1.08E-05

0.0149

ADAM Metallopeptidase Domain 7

down

 STRC

−4.876

7.30E-05

0.016

Stereocilin

down

 TKTL1

−4.824

6.83E-06

0.015

Transketolase Like 1

down

 CYP24A1

−4.770

0.0001

0.0167

Cytochrome P450 Family 24 Subfamily A Member 1

down

 MYT1

−4.708

0.0001

0.017

Myelin Transcription Factor 1

down

 ARHGEF5

−4.703

1.30E-05

0.015

Rho Guanine Nucleotide Exchange Factor 5

down

 ETFRF1

0.997

7.44E-05

0.015

Electron Transfer Flavoprotein Regulatory Factor 1

up

 H1–0

0.947

0.0006

0.023

H1.0 Linker Histone

up

 CHCHD1

0.790

0.001

0.028

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 1

up

 PECR

0.689

0.003

0.048

Peroxisomal Trans-2-Enoyl-CoA Reductase

up

 FBXO6

0.685

0.001

0.027

F-Box Protein 6

up

 ARL2

0.642

0.003

0.044

ADP Ribosylation Factor Like GTPase 2

up

 MRPL20

0.625

0.0007

0.024

Mitochondrial Ribosomal Protein L20

up

 WARS1

0.576

0.001

0.030

Tryptophanyl-TRNA Synthetase 1

up

 PSMB9

0.574

0.0007

0.023

Proteasome 20S Subunit Beta 9

up

 SNAPIN

0.560

0.003

0.046

SNAP Associated Protein

up

B) LOW vs NORM

 CADM1

−1.234

0.0002

0.041

Cell Adhesion Molecule 1

down

 CXCR4

−1.097

0.0001

0.036

C-X-C Motif Chemokine Receptor 4

down

 VRK2

−0.678

0.0002

0.042

VRK Serine/Threonine Kinase 2

down

 GXYLT1

−0.617

0.0003

0.043

Glucoside Xylosyltransferase 1

down

 SELENOI

−0.519

0.0002

0.039

Selenoprotein I

down

 TRMT13

−0.511

0.0001

0.036

TRNA Methyltransferase 13 Homolog

down

 PIKFYVE

−0.419

0.0004

0.043

Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing

down

 FSIP2

4.677

4.09E-05

0.026

Fibrous Sheath Interacting Protein 2

up

 XDH

4.661

7.57E-05

0.030

Xanthine Dehydrogenase

up

 IQCH

4.631

1.33E-05

0.026

IQ Motif Containing H

up

 DCST1

4.630

8.15E-05

0.031

DC-STAMP Domain Containing 1

up

 LIPN

4.557

3.09E-05

0.026

Lipase Family Member N

up

 CSMD3

4.452

6.03E-05

0.027

CUB And Sushi Multiple Domains 3

up

 ABCA12

4.450

4.66E-05

0.026

ATP Binding Cassette Subfamily A Member 12

up

 RNF17

4.409

3.85E-05

0.026

Ring Finger Protein 17

up

 ANO4

4.370

9.46E-05

0.032

Anoctamin 4

up

 CPN1

4.323

3.01E-05

0.026

Carboxypeptidase N Subunit 1

up

C) PreNxsex

 TEX11

−5.219

0.0004

0.023

Testis Expressed 11

down

 FAT2

−4.728

0.0004

0.023

FAT Atypical Cadherin 2

down

 FSIP2

−4.695

0.001

0.034

Fibrous Sheath Interacting Protein 2

down

 CCDC180

−4.534

0.002

0.042

Coiled-Coil Domain Containing 180

down

 ROBO3

−4.324

0.0005

0.024

Roundabout Guidance Receptor 3

down

 LIPN

−4.319

8.00E-05

0.018

Lipase Family Member N

down

 ABCA12

−4.286

0.0001

0.018

ATP Binding Cassette Subfamily A Member 12

down

 CNTNAP5

−4.220

0.002

0.042

Contactin Associated Protein Family Member 5

down

 CSMD3

−4.194

0.0001

0.018

CUB And Sushi Multiple Domains 3

down

 SLC26A5

−4.157

0.0001

0.018

Solute Carrier Family 26 Member 5

down

 ANKS4B

1.046

0.0007

0.029

Ankyrin Repeat And Sterile Alpha Motif Domain Containing 4B

up

 EPHA2

0.880

0.0002

0.019

EPH Receptor A2

up

 PTMA

0.820

0.0002

0.020

Prothymosin Alpha

up

 BTBD19

0.767

0.0002

0.019

BTB Domain Containing 19

up

 EGR2

0.660

0.001

0.036

Early Growth Response 2

up

 FBRS

0.630

0.0001

0.018

FAU Ubiquitin Like And Ribosomal Protein S30 Fusion

up

 MAPK8IP3

0.588

0.0006

0.026

Mitogen-Activated Protein Kinase 8 Interacting Protein 3

up

 PLEKHG2

0.568

0.001

0.036

Pleckstrin Homology And RhoGEF Domain Containing G2

up

 SYNDIG1L

0.567

0.0003

0.021

Synapse Differentiation Inducing 1 Like

up

 ARSL

0.560

0.0003

0.022

Arylsulfatase L

up

D) LOW-HCHF vs NORM-CONV

 LIPA

−3.246

6.49E-05

0.040

Lipase A, Lysosomal Acid Type

down

 FN1

−3.124

4.58E-06

0.021

Fibronectin 1

down

 ITGB2

−3.094

0.0001

0.040

Integrin Subunit Beta 2

down

 LGALS3

−3.054

1.21E-05

0.031

Galectin 3

down

 MSR1

−3.035

0.0002

0.041

Macrophage Scavenger Receptor 1

down

 MS4A8

− 3.025

0.0002

0.041

Membrane Spanning 4-Domains A8

down

 LCP1

− 3.029

5.66E-05

0.040

Lymphocyte Cytosolic Protein 1

down

 CAPG

−3.020

0.0002

0.044

Capping Actin Protein, Gelsolin Like

down

 CTSZ

−3.011

3.40E-05

0.040

Cathepsin Z

down

 C5AR1

−2.985

0.0002

0.040

Complement C5a Receptor 1

down

 FIBIN

1.384

0.0004

0.048

Fin Bud Initiation Factor Homolog

up

E) HIGH-HCHF vs NORM-CONV

 ACHE

−4.150

8.08E-05

0.033

Acetylcholinesterase (Cartwright Blood Group)

down

 ST14

−3.840

0.0003

0.038

ST14 Transmembrane Serine Protease Matriptase

down

 PADI2

−3.548

0.0002

0.036

Peptidyl Arginine Deiminase 2

down

 CRLF2

−3.385

0.0005

0.044

Cytokine Receptor Like Factor 2

down

 HTRA4

−3.358

0.0002

0.036

HtrA Serine Peptidase 4

down

 CD300E

−3.210

0.0004

0.040

CD300e Molecule

down

 S100A5

−3.211

0.0004

0.041

S100 Calcium Binding Protein A5

down

 NLRP1

−3.117

4.80E-05

0.033

NLR Family Pyrin Domain Containing 1

down

 HK3

−3.100

0.0001

0.033

Hexokinase 3

down

 ITGAX

−3.084

0.0004

0.040

Integrin Subunit Alpha X

down

 FIBIN

1.380

0.0004

0.040

Fin Bud Initiation Factor Homolog

up

 HMCN1

1.269

0.0003

0.038

Hemicentin 1

up

 ETNPPL

0.990

0.0006

0.047

Ethanolamine-Phosphate Phospho-Lyase

up

 ARHGAP20

0.837

0.0006

0.047

Rho GTPase Activating Protein 20

up

 DHRS12

0.780

0.0006

0.047

Dehydrogenase/Reductase 12

up

 LYRM1

0.740

0.0006

0.047

LYR Motif Containing 1

up

 TRIM13

0.593

0.0004

0.041

Tripartite Motif Containing 13

up

 DNAL1

0.589

0.0005

0.042

Dynein Axonemal Light Chain 1

up

 PDRG1

0.564

9.18E-05

0.033

P53 And DNA Damage Regulated 1

up

F) HCHF vs CONV

 SPP1

−4.788

5.45E-05

0.021

Secreted Phosphoprotein 1

down

 GPNMB

−4.412

2.55E-05

0.019

Glycoprotein Nmb

down

 TREM2

−3.924

3.08E-05

0.019

Triggering Receptor Expressed On Myeloid Cells 2

down

 SCIN

− 3.612

2.75E-05

0.019

Scinderin

down

 LIPA

−3.528

3.99E-05

0.020

Lipase A, Lysosomal Acid Type

down

 CAPG

−3.374

4.07E-06

0.010

Capping Actin Protein, Gelsolin Like

down

 S100A4

−3.350

2.19E-06

0.009

100 Calcium Binding Protein A4

down

 TYROBP

−3.248

6.54E-05

0.021

Transmembrane Immune Signaling Adaptor TYROBP

down

 CTSZ

−3.211

1.38E-05

0.019

Cathepsin Z

down

 MMP9

−3.170

0.0006

0.034

Matrix Metallopeptidase 9

down

 LIPN

5.163

3.63E-05

0.020

Lipase Family Member N

up

 DCST1

4.950

0.0002

0.027

DC-STAMP Domain Containing 1

up

 TEX11

4.896

1.88E-05

0.019

Testis Expressed 11

up

 ABCB5

4.823

0.0003

0.028

ATP Binding Cassette Subfamily B Member 5

up

 CCDC148

4.808

0.0001

0.023

Coiled-Coil Domain Containing 148

up

 FSIP2

4.802

0.0003

0.028

Fibrous Sheath Interacting Protein 2

up

 C6orf58

4.796

0.0004

0.030

Chromosome 6 Open Reading Frame 58

up

 MORC1

4.780

0.0006

0.033

MORC Family CW-Type Zinc Finger 1

up

 DKK1

4.776

6.43E-05

0.021

Dickkopf WNT Signaling Pathway Inhibitor 1

up

 CD28

4.642

3.12E-06

0.010

CD28 Molecule

up

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BMC Genomics

ISSN: 1471-2164

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