Table 3 Metascape functional term enrichment analysis of DEGs subfertile vs fertile mares
Most informative categories of Metascape enrichment analysis | Log10 (P-value) | Assigned genes |
|---|---|---|
Genes with lower expression in subfertile vs. fertile mares | ||
 Extracellular matrix, ECM-receptor interaction, Focal adhesion, Collagen trimer, PI3-Akt signaling pathway | −7.8 | COL4A1,COL4A2,COL6A1,FN1,ITGB3,THBS2,TNXB,COL16A1,C1QA,C1QB,ACHE,MMP25,FGFR1,JAK3,SLC39A8,ADAMTS7,PNPLA2,ANO8,DLG4,TIA1,PLCB2,PLXNA3,LLGL1,ACKR3,PDE2A,RYR1,ERFE,AKR1C4,CLK2 |
 Lymphocyte mediated immunity, complement activation, adaptive immune response | −4.4 | C1QA,C1QB,HLAA,IGHA1,IGHG1,IGHM,CLCF1,ULBP3,JAK3,FN1,DLG4,ENPP3,STAC,ACKR3,LAT,PREX1,IRF8,ITGB3 |
 Positive regulation of cytosolic calcium ion concentration, muscle contraction | −3.8 | DLG4,PLCB2,RYR1,NMU,ACKR3,SLC8B1,TPCN2,SLC39A8,ERFE,COL6A1,STAC,ITGB3,PNPLA2,FGFR1,SYT12,ATP8B2,ANO8,TNNT2 |
 Glycosaminoglycan binding | −3.8 | COL16A1,FGFR1,FN1,IGHM,THBS2,TNXB,ITGB3,PREX1,IGHA1,SLC8B1 |
 Regulation of immune effector process | −3.7 | C1QA,C1QB,DNASE1L3,HLA-A,IGHG1,JAK3,ENPP3, CLCF1,ULBP3 |
 Peptidyl-tyrosine phosphorylation | −3.5 | DLG4,FGFR1,FN1,ITGB3,JAK3,LAT,CLK1,CLK2,CLCF1,IGHG1,COL16A1,PLCB2 |
 Inorganic anion transport | −3.5 | DLG4,FGFR1,FN1,ITGB3,JAK3,LAT,CLK1,CLK2,CLCF1,IGHG1,COL16A1,PLCB2 |
 Phosphoric diester hydrolase activity | −3.4 | PDE2A,ENPP3,PLCB2,PDE10A,ENTPD6 |
 Receptor internalization, receptor-mediated endocytosis | −3.1 | ACHE,DLG4,ITGB3,ACKR3,IGHA1 |
 Hallmark Myogenesis, calcium ion binding | −3.1 | ACHE,COL4A2,RYR1,TNNT2,HSPB8,ENTPD6,SYT12,C1QA,DLG4,DNASE1L3,ENPP3,PLCB2,THBS2,RAB44 |
Genes with higher expression in subfertile vs. fertile mares | ||
 Monocarboxylic acid transmembrane transport activity | −5.6 | SLC10A2, SLC16A5, SLC16A9 |
 Protein targeting | −3.0 | RPL21,RPS17, TOMM7 |