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Table 3 Metascape functional term enrichment analysis of DEGs subfertile vs fertile mares

From: A comparative analysis of the intrauterine transcriptome in fertile and subfertile mares using cytobrush sampling

Most informative categories of Metascape enrichment analysis Log10 (P-value) Assigned genes
Genes with lower expression in subfertile vs. fertile mares
 Extracellular matrix, ECM-receptor interaction, Focal adhesion, Collagen trimer, PI3-Akt signaling pathway −7.8 COL4A1,COL4A2,COL6A1,FN1,ITGB3,THBS2,TNXB,COL16A1,C1QA,C1QB,ACHE,MMP25,FGFR1,JAK3,SLC39A8,ADAMTS7,PNPLA2,ANO8,DLG4,TIA1,PLCB2,PLXNA3,LLGL1,ACKR3,PDE2A,RYR1,ERFE,AKR1C4,CLK2
 Lymphocyte mediated immunity, complement activation, adaptive immune response −4.4 C1QA,C1QB,HLAA,IGHA1,IGHG1,IGHM,CLCF1,ULBP3,JAK3,FN1,DLG4,ENPP3,STAC,ACKR3,LAT,PREX1,IRF8,ITGB3
 Positive regulation of cytosolic calcium ion concentration, muscle contraction −3.8 DLG4,PLCB2,RYR1,NMU,ACKR3,SLC8B1,TPCN2,SLC39A8,ERFE,COL6A1,STAC,ITGB3,PNPLA2,FGFR1,SYT12,ATP8B2,ANO8,TNNT2
 Glycosaminoglycan binding −3.8 COL16A1,FGFR1,FN1,IGHM,THBS2,TNXB,ITGB3,PREX1,IGHA1,SLC8B1
 Regulation of immune effector process −3.7 C1QA,C1QB,DNASE1L3,HLA-A,IGHG1,JAK3,ENPP3, CLCF1,ULBP3
 Peptidyl-tyrosine phosphorylation −3.5 DLG4,FGFR1,FN1,ITGB3,JAK3,LAT,CLK1,CLK2,CLCF1,IGHG1,COL16A1,PLCB2
 Inorganic anion transport −3.5 DLG4,FGFR1,FN1,ITGB3,JAK3,LAT,CLK1,CLK2,CLCF1,IGHG1,COL16A1,PLCB2
 Phosphoric diester hydrolase activity −3.4 PDE2A,ENPP3,PLCB2,PDE10A,ENTPD6
 Receptor internalization, receptor-mediated endocytosis −3.1 ACHE,DLG4,ITGB3,ACKR3,IGHA1
 Hallmark Myogenesis, calcium ion binding −3.1 ACHE,COL4A2,RYR1,TNNT2,HSPB8,ENTPD6,SYT12,C1QA,DLG4,DNASE1L3,ENPP3,PLCB2,THBS2,RAB44
Genes with higher expression in subfertile vs. fertile mares
 Monocarboxylic acid transmembrane transport activity −5.6 SLC10A2, SLC16A5, SLC16A9
 Protein targeting −3.0 RPL21,RPS17, TOMM7