Fig. 5

Comparison of the five identified consensus motifs to IMEter. Density plot of intra-set Pearson correlation of gene expression comparing (a), the 2000 genes with the highest IMEter score (top_imeter) to a subset of random genes of equal size, (b), genes containing of one of the five identified candidate motifs and genes containing the IMEter-derived motifs TTNGATYTG and CGATT, designated by asterisks. Each gene set was compared to a subset of genes with the highest IMEter score of equal set size and their difference expressed as Cohen’s d effect size, given in the graph titles, with negative values suggesting smaller effect in motif-set relative to size-matched IMEter-score set. (c) same as in (b), but with overlapping genes (genes found in both sets) removed from the IMEter set. Intra-set Pearson correlation refers to the determined Pearson correlation coefficients of all possible gene pairs in sets of genes harboring the same motif or belonging to the same top-IMEter set