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Table 2 Top10 differentially expressed up-regulated and down-regulated mRNAs

From: Transcriptome profiling of the diaphragm in a controlled mechanical ventilation model reveals key genes involved in ventilator-induced diaphragmatic dysfunction

mRNA ID

Log2FC

P-value

Up/down

Product

Pdk4

4.31

7.60E-46

Up

pyruvate dehydrogenase kinase 4

Cep85l

2.65

2.30E-37

Up

centrosomal protein 85-like

Mt1

7.53

1.20E-31

Up

metallothionein 1

Mt2A

7.63

2.49E-31

Up

metallothionein 2 A

Ifitm1

2.65

9.42E-27

Up

interferon induced transmembrane protein1

Angptl4

4.43

2.48E-26

Up

angiopoietin-like 4

Enc1

2.75

2.65E-25

Up

ectodermal-neural cortex 1

Hmgcs2

5.76

6.28E-25

Up

3-hydroxy-3-methylglutaryl-CoA synthase 2

Acer2

1.95

1.62E-22

Up

alkaline ceramidase 2

Hmox1

4.32

3.88E-22

Up

heme oxygenase 1

Nmrk2

-3.68

2.26E-26

Down

nicotinamide riboside kinase 2

Acly

-1.97

3.73E-23

Down

ATP citrate lyase

Pnpla3

-3.63

1.40E-22

Down

patatin-like phospholipase domain containing 3

Papln

-2.84

1.38E-18

Down

papilin, proteoglycan-like sulfated glycoprotein

Tp53i3

-2.69

1.23E-16

Down

tumor protein p53 inducible protein 3

Oxtr

-4.60

1.84E-16

Down

oxytocin receptor

Dnah5

-1.70

1.19E-15

Down

dynein, axonemal, heavy chain 5

Islr

-2.09

1.81E-15

Down

immunoglobulin superfamily containing leucine-rich repeat

Itga6

-1.42

4.75E-15

Down

integrin subunit alpha 6

Mss51

-3.30

2.57E-14

Down

MSS51 mitochondrial translational activator