Fig. 2

Members of most snoRNA families cover a large range of abundance values. A, B The majority of annotated human snoRNAs are members of Rfam families consisting of at least two human members (labelled as ‘Multi member families’) as shown using pie charts for box C/D (A, top panel) or H/ACA (B, top panel) snoRNAs. Families can have up to dozens of members in human, but most members have an abundance below the detectable limit (‘Not detected’, panels A and B, bottom pie charts). C, D Stacked bar charts showing the number of members for box C/D (C) and box H/ACA (D) families. Only families with at least 3 and less than 100 members are shown (for full graphs, see Figs. S1, S2). Members with abundance greater than 1 TPM in at least 1 tissue sample considered are indicated in a darker shade while non-detected members are indicated in a lighter shade. Green family names represent families with at least two identical members. E, F Family members display high levels of pairwise sequence identity. Boxplots measuring the level of pairwise sequence identity between all members of indicated families, for box C/D families in red (E) and H/ACA families in blue (F). G, H For many families, the abundance of members spans at least 3 orders of magnitude. Box plots showing the distribution of average abundance across all tissues considered of members of the indicated C/D (G) and H/ACA (H) families