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Table 3 Differentially expressed genes in the hypertrophic region of dorsal lip in Gnathochromis permaxillaris with related functions in vertebrates

From: Transcriptomics unravels molecular players shaping dorsal lip hypertrophy in the vacuum cleaner cichlid, Gnathochromis permaxillaris

Gene Related function Organism References
apoda A multi-ligand transporter involved in neural cell survival
found to be repressed in lip tissue of thick-lipped Midas cichlid
Human
Mouse
Cichlid
(Dassati, Waldner & Schweigreiter, 2014) [30] (Manousaki et al., 2013) [7]
cyp1a Involved in xenobiotic and steroid metabolism and associated with lip and palate cleft and cancers Human (Linnenkamp et al., 2020) [31] (Stuppia et al., 2011) [32]
fhl2 A transcriptional modulator of cell proliferation and apoptosis, found to be repressed in lip tissue of thick-lipped Midas cichlid Human
Cichlid
(Ng et al., 2011) [33] (Labalette et al., 2008) [34] (Manousaki et al., 2013) [7]
foxf1 Micro-deletion causes lip and palate deformities Human
Mouse
(Shaw-Smith, 2010) [35] (Xu et al., 2016) [36]
foxp1 Non-functional mutation causes pronounced vermilion border of upper lip Human (Meerschaut et al., 2017) [37]
gimap8 A GTP-binding protein with role in immunity and apoptosis, found to be repressed in lip tissue of thick-lipped Midas cichlid Cichlid (Manousaki et al., 2013) [7]
igf2 Expression changes in Russell–Silver syndrome leads to thin vermilion border of upper lip Human (Peñaherrera et al., 2010) [38]
lama5 An extracellular matrix glycoprotein mediating the attachment, migration and organization of cells into tissues, and implicated in lip inflammation and carcinogenesis Human (Peixoto da-Silva et al., 2012) [39]
rasal3 A negative regulator of Ras pathway and its duplication and deletion are both linked to defective lip morphogenesis Human (Draaken et al., 2013) [40] (Kosaki et al., 2011) [41]
Trim37 A tripartite motif family member involved in developmental patterning and its mutation causes lip and palate cleft Human (Kumpf et al., 2013) [42]
tcf12 Non-functional mutation causes thin upper lip and craniofacial deformities Human (Piard et al., 2015) [43]