Fig. 2
From: A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
The spectrum and specificity of HIF1α-DNA binding complexes of the lens genome. A Heatmap of HIF1α binding signal compared to IgG signal at all genomic regions containing HIF1α-DNA binding complexes identified by CUT&RUN. B De novo motif analysis of HIF1α-DNA binding complexes identified by CUT&RUN. The canonical HIF1α consensus sequence was the most significantly enriched motif (E-value 3.6 × 10− 111). C Percent of the 8375 HIF1α-DNA binding complexes identified by CUT&RUN that were found within the indicated distances from the nearest gene transcription start site. D Relative percentage difference between the distribution of HIF1α-DNA binding complexes identified by CUT&RUN compared to computer generated HIF1α-DNA binding complexes randomly distributed across the genome and sorted by distance to the nearest gene transcription start site. (X2-test, p < 2.2 × 10− 16). E Percent of the 8375 HIF1α-DNA binding complexes identified by CUT&RUN that were found within proximal promoter regions (+/− 3kbp of gene transcription start sites), genebodies, or intergenic regions. F Relative percentage difference between the distribution of HIF1α-DNA binding complexes identified by CUT&RUN compared to computer generated HIF1α-DNA binding complexes randomly distributed across the genome and classified as found within proximal promoter regions (+/− 3kbp of gene transcription start sites), genebodies, or intergenic regions. (X2-test, p < 1 × 10− 11)