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Table 2 Genomic location of the significant Quantitative Trait Loci (QTL) at 90 and 95% genome wide significant thresholds associated with polyp counts in SB1, SB2, SB3, Colon and total polyps in the entire intestines (SB1–3 and colon) regions of different CC lines. QTL associated with polyp counts detected on different chromosomal regions. Experiment-wide thresholds of significance at *P% of 50, 90 and 95% levels are presented for each trait, accordingly

From: Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross mice

Trait

logP

Chrs

QTL

Peak (Mb)

CI 50%

Size

(Mb)

[Genes]

CI 90%

Size

(Mb)

[Genes]

CI 95%

Size

(Mb)

[Genes]

*90%

**95%

SB1

3.71

4.43

Chr3

Mom19**

13.839

13.434–14.321 (0.88) [12]

11.203–17.131 (5.93) [49]

9.902–19.627 (9.72) [104]

Chr12

Mom20*

111.371

110.004–113.284 (3.28) [104]

103.706–117.303 (13.60) [610]

102.018–118.857 (16.84) [670]

SB2

3.83

4.11

Chr10

Mom21**

18.805

17.208–20.747 (3.54) [46]

9.550–27.338 (17.79) [234]

8.902–28.471 (19.57) [245]

Chr16

Mom22**

53.511

52.785–56.096 (3.31) [34]

48.038–62.078 (14.04) [186]

45.522–63.132 (17.61) [226]

Mom23**

73.216

72.224–73.812 (1.59) [9]

69.722–76.406 (6.68) [51]

68.716–78.148 (9.43) [73]

SB3

3.90

4.20

Chr6

Mom24**

146.203

145.502–146.376 (0.87) [8]

140.899–147.303 (6.40) [103]

138.051–147.806 (9.76) [135]

Chr12

Mom25**

113.449

112.966–113.893 (0.93) [96]

110.997–115.709 (4.71) [299]

109.825–116.663 (6.84) [375]

Chr9

Mom26*

37.552

35.326–39.645 (4.32) [176]

32.692–42.502 (9.81) [271]

32.557–42.557 (10.00) [273]

Chr10

Mom21*

18.805

16.268–20.395 (4.13) [48]

9.921–25.465 (15.54) [211]

8.950–27.582 (18.63) [238]

Colon

3.87

4.19

Chr6

Mom27**

35.915

35.651–36.331 (0.68) [3]

35.031–37.665 (2.63) [27]

34.720–38.392 (3.67) [59]

Total polyps

3.86

4.23

Chr12

Mom20**

111.636

111.349–112.016 (0.67) [26]

109.935–113.616 (3.68) [156]

109.525–113.920 (4.39) [284]

Chr16

Mom22**

53.489

51.882–56.475 (4.59) [42]

45.709–62.530 (16.82) [211]

44.055–63.294 (19.24) [258]

Mom23**

73.556

72.068–74.972 (2.90) [18]

68.468–80.424 (11.96) [93]

65.848–83.013 (17.16) [119]

  1. **95%, *90% levels of genome wide significance thresholds