Fig. 4

Comparative analysis methodology and correlated repair rates between human and mouse lemur. A) Approach to identify orthologous regions between human and mouse lemur (see methods for details). B) Scatter plots showing the normalized repair levels between two organisms. Relative repair was calculated by normalizing the repair signal by the simulated XR-seq reads to eliminate the sequence context bias. C) Mapped orthologous regions with repair and transcription profiles mapped at left and right outer rings, respectively. Inner circle represents the human (left) and mouse lemur (right) chromosomes. Inner lines connecting orthologous regions are colored based on the human chromosome color scale. Repair and transcription values (outer rings) for genomic regions that have no evident ortholog (based on the criteria in A) are not shown