Gene co-expression network analysis in zebrafish reveals chemical class specific modules

BMC Genomics

Table 4 Genes with the highest degrees from the modules associated with FRC exposure (Modules 2, 7, and 10)

Module	Degree	Gene	Name	Known function in zebrafish from previous studies	Reference
2	32	mxd1	Max Dimerization Protein 1	unknown
	31	zgc.158689	unidentified	unknown
	30	osbpl2a	oxysterol binding protein-like 2a	unknown
	30	srgap3	Slit-Robo GTPase activating protein 3	role in neurodevelopmental processes	[46]
	30	tfe3a	Transcription factor-binding to IGHM enhancer 3a	Part of the MiT family coding for basic-helix-loop-helix/leucine zipper class transcription factors	[47]
	30	cacna1da	calcium channel, voltage-dependent, L type, alpha 1D subunit, a	calcium channel-related gene whose expression was shown to be altered by triadimefon, a broad-spectrum fungicide, and silica nanoparticle exposures to embryonic zebrafish	[48, 49]
7	18	NA_1170	uncharacterized
	12	purab	Purine-rich element-binding protein Ab	unknown
	11	sgsm1a	small G protein signaling modulator 1a	associated with small G protein-mediated signal transduction	[50]
	10	fermt2	fermitin family member 2	part of the Kindlin or Fermitin family of scaffold proteins important for signaling across membrane-spanning integrin adhesion receptors	[51]
10	10	apc2	APC regulator of WNT signaling pathway 2	in the family of genes coding for a regulator of the WNT signaling pathway	[45]
	10	celsr3	cadherin, EGF LAG seven-pass G-type receptor 3	plays a role in the facial motor neuron migration in zebrafish	[52]
	9	adam22	ADAM metallopeptidase domain 22	unknown
	9	NA_108	unidentified	unknown

ISSN: 1471-2164