Early life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in rats

McKibben, Lauren Allen; Dwivedi, Yogesh

doi:10.1186/s12864-021-08003-4

Table 1 miRNAs altered by the interaction between maternal separation, restraint stress, and sex

From: Early life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in rats

		CPM-Fold Change
Accession ID	miRNA	MS: Control				p	Sig.
maternal separation
MIMAT0012855	miR-666-5p	1.33				0.046	*
MIMAT0017819	miR-3557-5p	1.28				0.044	*
MIMAT0000838	miR-132-3p	1.28				0.005	*
MIMAT0003379	miR-378a-3p	1.28				0.024	*
MIMAT0017158	miR-212-5p	1.25				0.008	*
MIMAT0003378	miR-378a-5p	1.21				0.026	*
MIMAT0035730	miR-1843b-5p	1.20				0.025	*
MIMAT0000859	miR-181b-5p	1.19				0.020	*
MIMAT0003205	miR-409a-3p	1.18				0.030	*
MIMAT0000550	miR-323-3p	1.16				0.024	*
MIMAT0001626	miR-431	1.12				0.033	*
MIMAT0003194	miR-376c-3p	1.10				0.050	*
MIMAT0000832	miR-126a-3p	1.09				0.028	*
MIMAT0004706	let-7e-3p	1.08				0.028	*
MIMAT0004732	miR-135a-3p	−1.11				0.046	*
MIMAT0000805	miR-30e-5p	− 1.18				0.034	*
MIMAT0004726	miR-101a-5p	− 1.20				0.042	*
MIMAT0017026	miR-301a-5p	−1.20				0.046	*
MIMAT0017143	miR-186-3p	−1.21				0.022	*
MIMAT0005328	miR-673-5p	−1.21				0.006	*
MIMAT0035720	let-7 g-3p	−1.23				0.031	*
MIMAT0017839	miR-3065-5p	−1.24				0.033	*
MIMAT0000812	miR-33-5p	−1.31				0.039	*
MIMAT0017230	miR-497-3p	−1.39				0.024	*
MIMAT0005304	miR-301b-3p	−1.56				0.011	*
MIMAT0005445	miR-29b-1-5p	−1.71				0.012	*
MIMAT0017154	miR-206-5p	−1.77				0.017	*
MIMAT0000850	miR-144-3p	−1.78				0.011	*
restraint stress		RS:Control
MIMAT0017881	miR-3586-3p	1.26				0.016	*
MIMAT0000791	miR-22-3p	1.21				0.014	*
MIMAT0000784	miR-15b-5p	1.20				0.008	*
MIMAT0003380	miR-505-3p	1.20				0.011	*
MIMAT0003193	miR-494-3p	1.20				0.029	*
MIMAT0017840	miR-3065-3p	1.19				0.038	*
MIMAT0003175	miR-543-3p	1.17				0.038	*
MIMAT0000794	miR-24-3p	1.17				0.012	*
MIMAT0000792	miR-23a-3p	1.17				0.034	*
MIMAT0000793	miR-23b-3p	1.17				0.002	**
MIMAT0004714	miR-26b-3p	1.17				0.030	*
MIMAT0035719	let-7 g-5p	1.13				0.040	*
MIMAT0000840	miR-134-5p	−1.09				0.040	*
MIMAT0017307	miR-434-5p	−1.10				0.047	*
MIMAT0017306	miR-425-3p	−1.10				0.016	*
MIMAT0005339	miR-873-5p	−1.11				0.037	*
MIMAT0017031	miR-329-5p	−1.11				0.010	*
MIMAT0017137	miR-181c-3p	−1.13				0.040	*
MIMAT0000902	miR-300-3p	−1.13				0.023	*
MIMAT0005332	miR-708-3p	−1.14				0.043	*
MIMAT0017117	miR-127-5p	−1.14				0.009	*
MIMAT0004655	miR-345-3p	−1.14				0.015	*
MIMAT0005341	miR-488-3p	−1.15				0.026	*
MIMAT0003192	miR-379-5p	−1.15				0.001	***
MIMAT0024847	miR-1843a-5p	−1.15				0.030	*
MIMAT0003199	miR-381-3p	− 1.16				0.012	*
MIMAT0000781	miR-9a-5p	−1.17				0.016	*
MIMAT0004728	miR-124-5p	−1.18				0.027	*
MIMAT0000802	miR-29a-3p	−1.18				0.012	*
MIMAT0004740	miR-218a-2-3p	−1.19				0.012	*
MIMAT0005312	miR-411-5p	−1.20				0.002	**
MIMAT0017334	miR-146b-3p	− 1.20				0.010	*
MIMAT0000833	miR-127-3p	−1.21				0.014	*
MIMAT0005308	miR-380-5p	−1.21				0.005	**
MIMAT0017360	miR-582-3p	−1.22				0.016	*
MIMAT0017828	miR-3559-3p	−1.22				0.018	*
MIMAT0017291	miR-879-3p	−1.22				0.007	*
MIMAT0000587	miR-341	−1.23				0.004	**
MIMAT0005325	miR-598-3p	−1.24				0.002	**
MIMAT0001534	miR-448-3p	−1.27				0.024	*
MIMAT0000814	miR-34c-5p	−1.28				0.014	*
MIMAT0024856	miR-6216	−1.39				0.038	*
MIMAT0017896	miR-3593-5p	−1.84				0.045	*
sex		Female:Male
MIMAT0004712	miR-23a-5p	1.97				0.031	*
MIMAT0004739	miR-204-3p	1.58				0.027	*
MIMAT0000877	miR-204-5p	1.29				0.023	*
MIMAT0017802	miR-3547	1.27				0.039	*
MIMAT0004729	miR-125a-3p	1.21				0.045	*
MIMAT0003378	miR-378a-5p	1.20				0.030	*
MIMAT0001549	miR-365-3p	1.19				0.016	*
MIMAT0017175	miR-421-3p	1.18				0.000	***
MIMAT0004648	miR-339-3p	1.16				0.043	*
MIMAT0004740	miR-218a-2-3p	1.15				0.041	*
MIMAT0017306	miR-425-3p	1.11				0.011	*
MIMAT0000774	let-7a-5p	1.11				0.043	*
MIMAT0000796	miR-26a-5p	1.09				0.006	*
MIMAT0005335	miR-758-3p	−1.11				0.034	*
MIMAT0005299	miR-181d-5p	−1.12				0.046	*
MIMAT0003207	miR-369-3p	−1.13				0.022	*
MIMAT0017867	miR-3579	−1.20				0.039	*
MIMAT0017192	miR-433-5p	−1.22				0.038	*
MIMAT0005311	miR-410-3p	−1.27				0.007	*
MIMAT0017136	miR-154-3p	−1.37				0.022	*
MIMAT0017130	miR-144-5p	−1.49				0.017	*
MIMAT0001633	miR-451-5p	−1.73				0.006	*
MIMAT0000850	miR-144-3p	−1.83				0.008	*
MIMAT0012851	miR-547-3p	−2.45				0.000	***
MS x RS		MS: Control		MS + RS: RS
MIMAT0017117	miR-127-5p	−1.12		1.11		0.028	*
MIMAT0005325	miR-598-3p	−1.15		1.14		0.038	*
MIMAT0017851	miR-3571	−1.31		1.42		0.020	*
MIMAT0017818	miR-3556b	−1.31		1.01		0.043	*
MIMAT0001534	miR-448-3p	−1.37		1.13		0.031	*
MS x sex		MS Male: Control Male		MS Female: Control Female
MIMAT0012830	miR-504	1.28		−1.20		0.044	*
MIMAT0005278	miR-466b-5p	1.03		−1.19		0.047	*
MIMAT0000839, MIMAT0003126	miR-133a/b-3p	−1.12		1.49		0.047	*
MIMAT0037263	miR-1b	−1.19		1.59		0.043	*
MIMAT0017131	miR-145-3p	−1.29		1.83		0.049	*
MIMAT0017838	miR-218b	−1.33		1.10		0.023	*
MIMAT0017851	miR-3571	−1.35		1.43		0.014	*
MIMAT0017823	miR-3596d	−1.39		1.08		0.042	*
MIMAT0017886	miR-3596a	−1.45		1.11		0.041	*
MIMAT0017887	miR-3588	−1.58		1.25		0.030	*
MIMAT0000850	miR-144-3p	−2.30		−1.16		0.037	*
RS x sex		RS Male: Control Male		RS Female: Control Female
MIMAT0000886	miR-216a-5p	1.48		−1.35		0.035	*
MIMAT0017136	miR-154-3p	1.46		−1.15		0.044	*
MIMAT0000801	miR-29b-3p	1.43		−1.09		0.040	*
MIMAT0003195	miR-376b-5p	1.41		−1.07		0.040	*
MIMAT0012833	miR-582-5p	1.39		−1.27		0.025	*
MIMAT0004743	miR-300-5p	1.38		−1.16		0.007	*
MIMAT0000552	miR-301a-3p	1.37		−1.15		0.049	*
MIMAT0012834	miR-592	1.35		−1.18		0.033	*
MIMAT0000577	miR-337-3p	1.32		−1.12		0.050	*
MIMAT0005301	miR-188-5p	1.30		−1.11		0.032	*
MIMAT0004791	miR-379-3p	1.30		−1.16		0.042	*
MIMAT0003196	miR-376b-3p	1.27		− 1.16		0.014	*
MIMAT0017143	miR-186-3p	1.24		−1.14		0.031	*
MIMAT0024845	miR-3068-5p	1.23		−1.18		0.022	*
MIMAT0017223	miR-374-3p	1.20		−1.22		0.046	*
MIMAT0017146	miR-191a-3p	1.19		−1.11		0.027	*
MIMAT0000813	miR-34b-5p	1.18		−1.46		0.016	*
MIMAT0017111	miR-98-3p	1.17		−1.17		0.038	*
MIMAT0000888	miR-218a-5p	1.15		−1.22		0.017	*
MIMAT0017213	miR-541-3p	1.14		−1.24		0.007	*
MIMAT0017127	miR-138-2-3p	1.14		−1.12		0.018	*
MIMAT0017100	miR-26a-3p	1.13		−1.08		0.024	*
MIMAT0005335	miR-758-3p	1.11		−1.11		0.041	*
MIMAT0003191	miR-493-3p	1.09		−1.17		0.022	*
MIMAT0017212	miR-539-3p	1.08		−1.30		0.034	*
MIMAT0024846	miR-3068-3p	1.07		−1.13		0.012	*
MIMAT0017874	miR-3583-3p	1.07		−1.17		0.048	*
MIMAT0017307	miR-434-5p	1.03		−1.26		0.011	*
MIMAT0000791	miR-22-3p	1.02		1.41		0.028	*
MIMAT0004733	miR-136-3p	1.02		−1.52		0.048	*
MIMAT0005339	miR-873-5p	1.00		−1.24		0.037	*
MIMAT0017137	miR-181c-3p	−1.00		−1.26		0.041	*
MIMAT0017360	miR-582-3p	−1.02		−1.46		0.033	*
MIMAT0017117	miR-127-5p	−1.03		− 1.27		0.036	*
MIMAT0001534	miR-448-3p	−1.03		− 1.54		0.047	*
MIMAT0005331	miR-708-5p	− 1.04		1.17		0.033	*
MIMAT0005308	miR-380-5p	−1.06		− 1.41		0.041	*
MIMAT0004705	let-7b-3p	−1.06		1.27		0.041	*
MIMAT0004648	miR-339-3p	−1.15		1.18		0.043	*
MIMAT0017871	miR-3596b	−1.19		1.48		0.012	*
MIMAT0017886	miR-3596a	−1.20		1.37		0.031	*
MIMAT0017877	miR-3596c	−1.25		1.36		0.024	*
MIMAT0000903	miR-320-3p	−1.28		1.47		0.037	*
MIMAT0017094	miR-16-3p	−1.28		1.18		0.017	*
MIMAT0005313	miR-423-3p	−1.30		1.52		0.039	*
MIMAT0017866	miR-3578	−1.33		1.35		0.031	*
MS x RS x sex		MS Male: C Male	MS Female: C Female	MS RS Male: RS Male	MS RS Female: RS Female
MIMAT0017100	miR-26a-3p	1.21	−1.02	− 1.07	1.25	0.009	*

All miRNAs with a significant main effect or interaction effect are listed here. CPM-fold change is presented as a ratio one group’s miRNA expression over another group (usually the comparison control). Positive values indicate upregulation and negative values show downregulation. *p < 0.05, **p < 0.005, ***p < 0.001. Abbreviations: CPM-counts per million, MS-maternal separation, RS-restraint stress, C-control

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Genomics

Contact us