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Fig. 1 | BMC Genomics

Fig. 1

From: Accelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson’s disease

Fig. 1

(A) Conceptual model of the relationship between mitotic age and the estimated epigenetic mitotic age (epiTOC pcgtAge), aging, inflammation/inflamm-aging, hematopoiesis, and Parkinson’s disease. (B) Current understanding of hematopoietic cell lineages for the circulating leukocytes estimated with the Houseman method. Cell lifespan and the normal proportion of cells in white blood cell (WBC) counts are displayed in the grey box, as well as the suggested influence of aging and inflammation. See A. Wickrema 2009 for more detail[4]

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BMC Genomics

ISSN: 1471-2164

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