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Fig. 4 | BMC Genomics

Fig. 4

From: Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen

Fig. 4

Chord plots of top significantly enriched gene ontologies associated with adenovirus and modified vaccinia Ankara immunisation in mice. Significantly differentially expressed genes (DEGs) (FDR < 0.05) associated with a single dose of human adenovirus serotype 5 or modified vaccinia Ankara encoding a factor H binding protein transgene (Ad-fHbp and MVA-fHbp, respectively), 24 h after a single dose were analysed for enrichment of gene ontology (GO) categories. GO categories containing greater than three of the top significantly DEGs were included in the chord plots and their names are displayed along the right hemisphere of each plot. The names of the proteins encoded by the corresponding DEGs were ranked according to the gene’s log2 fold-change along the left hemisphere, from highest to lowest. a Ad-fHbp. b MVA-fHbp

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BMC Genomics

ISSN: 1471-2164

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