Table 4 Five topmost significantly enriched biological functions for RFI and its component traits, and genes involved in functions
Trait1 | Biological function | P-value range2 | Genes involved in the biological function |
|---|---|---|---|
RFI | Cellular Assembly and Organization | 7.92E-05 – 4.19E-02 | ADGRF1, ADGRF5, ANXA8L1, ATG3, BOC, CD2AP, DAB1, DYNC1LI1, ESR2, FGF12, ITPR2, KATNA1, LATS1, NEDD4, SHROOM3, SPICE1, SYNE2 |
Cell Morphology | 1.02E-03 – 4.02E-02 | ADGRF5, ATG3, BOC, CD2AP, ESR2, KATNA1, LATS1, NEDD4, SLC9A9, SYNE2 | |
Cellular Function and Maintenance | 1.02E-03 – 4.19E-02 | ADGRF1, ADGRF5, ANXA8L1, ATG3, BOC, CD2AP, DAB1, DYNC1LI1, ESR2, FGF12, ITPR2, KATNA1, NEDD4, SHROOM3, SYNE2 | |
Cellular Movement | 1.12E-03 – 2.87E-02 | DAB1, ESR2, KATNA1 | |
Molecular Transport | 1.28E-03 – 3.36E-02 | ADGRF5, DAB1, ESR2, ITPR2, LATS1, SHROOM3 | |
DMI | Lipid Metabolism | 2.46E-04 – 2.81E-02 | ACACB, ADGRF5, ALDH3B1, AQP9, CCDC80, CHKA, CPT1A, DAB1, DDX5, HNF1A, IGHMBP2, LRP5, NOS1, PLSCR1, PVALB, SSPN |
Molecular Transport | 2.46E-04 – 2.54E-02 | ACACB, ADGRF5, AQP9, CCDC80, CD247, CHKA, CPT1A, DAB1, DDX5, FGF12, HNF1A, IFT27, IGHMBP2, ITPR2, LRP5, NEDD4, NOS1, NPFFR2, PECAM1, PLSCR1, PVALB, TCIRG1 | |
Small Molecule Biochemistry | 2.46E-04 – 2.81E-02 | ACACB, ADGRF5, ALDH3B1, AQP9, CCDC80, CHKA, CPT1A, DAB1, DDX5, HNF1A, HS6ST3, IGHMBP2, LRP5, NOS1, NPFFR2, PECAM1, PLSCR1, PVALB, SGCD, SSPN, TCIRG1 | |
Nucleic Acid Metabolism | 2.84E-04 – 2.81E-02 | ACACB, CPT1A, NOS1 | |
Protein Synthesis | 5.66E-04 – 1.13E-02 | ACACB, CCDC80, HNF1A, LRP5, NOS1, NPFFR2, PECAM1, SGCD | |
ADG | Cell-To-Cell Signaling and Interaction | 6.57E-04 – 6.57E-04 | TRAF3 |
Cellular Development | 6.57E-04 – 2.34E-02 | TRAF3 | |
Cellular Function and Maintenance | 6.57E-04 – 2.21E-02 | AMN, ARL8B, MYO19, TRAF3 | |
Cellular Growth and Proliferation | 6.57E-04 – 2.34E-02 | TRAF3 | |
Molecular Transport | 6.57E-04 – 2.34E-02 | AMN, ARL8B, CA4, SLC28A3, TRAF3 | |
MWT | Molecular Transport | 7.04E-04 – 4.79E-02 | AMN, AQP9, ARL8B, ATP6V0A4, CA4, CAMK2B, DDX56, DDX6, NPC1L1, PPP3CC, SLC28A3, SORBS3, TRAF3, TRAK1 |
Nucleic Acid Metabolism | 7.04E-04 – 2.7E-02 | AQP9, SLC28A3 | |
Small Molecule Biochemistry | 7.04E-04 – 4.79E-02 | AMN, AQP9, NPC1L1, PPP3CC, SLC28A3, SORBS3, TREH | |
Cell Cycle | 1.45E-03 – 2.78E-02 | ARL8B, CAMK2B, MYO19, NUDCD3, TRIM24 | |
Cell Morphology | 1.45E-03 – 3.36E-02 | AQP9, ARL8B, CAMK2B, NUDCD3, PDLIM2, PINX1, TRIM24 |