Fig. 3

An RBPMS-MET fusion identified in a patient with an infantile fibrosarcoma-like tumor. A RBPMS-MET fusion was identified by all seven fusion callers in the filtered overlap results. The number of fusions identified by each caller is in the outer VENN diagram sections, while internal numbers indicate overlapping fusions found post-filtering (0 overlaps between callers are not shown). B The RBPMS-MET fusion is an interchromosomal event, occurring between 8p12 and 7q31.2 and joining exon 5 of RBPMS (blue) to exon 15 of MET (red). C The fusion protein product includes the RNA recognition motif domain of RBPMS and the tyrosine kinase catalytic domain of MET. D The RBPMS-MET fusion is predicted to cause constitutive phosphorylation and activation of MET, targetable using cabozantinib. All images depicted in the associated figure are the authors’ own and not taken from another source