Integration of transcriptomics and network analysis reveals co-expressed genes in Frankliniella occidentalis larval guts that respond to tomato spotted wilt virus infection

Table 2 Intramodular network hub gene connectivity in co-expression modules enriched with differentially-expressed transcripts responsive to tomato spotted wilt virus

Module network	Hub transcript ID	^akME; kIN	Gene description	^bLog₂ fold change
Module network	Hub transcript ID	^akME; kIN	Gene description	3-L1	48-L2
Turquoise	FOCC013756	0.801; 8.036	cytochrome p450 (^cCYP3653A2)	−1.09	–
	FOCC012444	0.685; 6.274	uncharacterized protein	−1.33	–
	FOCC012265	0.693; 5.767	myrosinase 1-like	−1.65	1.88
Blue	FOCC009188	0.969; 9.711	hypothetical protein	1.64	–
	FOCC004976	0.938; 9.121	lysozyme X-like isoform X1	1.65	–
	FOCC013675	0.885; 6.677	lysosomal alpha-mannosidase	1.25	–
Light cyan	FOCC014803	0.981; 17.448	^dendocuticle structural glycoprotein	3.33	−3.83
	FOCC017589	0.980; 16.886	cytochrome p450 (^cCYP4G236)	2.82	–
	FOCC007741	0.985; 17.065	troponin C, isoform 1	–	−2.89
	FOCC001084	0.977; 16.152	cuticle protein 6-like	–	−3.69

^amodule membership (kME) and intramodular connectivity (kIN) calculated using methodology from Langfelder and Horvath, 2008 [36] (WGCNA R package, updated version February 16, 2016); ^b RNA-Seq analysis of normalized read counts between tomato spotted wilt virus-infected thrips relative to non-infected thrips; ^c CYP nomenclature from Rotenberg et al., 2020 [35]; ^d TSWV-interacting protein, endoCP-G_N [33]

ISSN: 1471-2164