Genetic association tests in family samples for multi-category phenotypes

BMC Genomics

Table 1 Simulation results of type-I error for family-based samples

MAF	Robust Score test			Wald test			Logistic regression (LRT)
MAF	α = 0.01	α = 0.001	α = 0.0001	α = 0.01	α = 0.001	α = 0.0001	α = 0.01	α = 0.001	α = 0.0001
0.01	0.014	0.0020	0.0003	0.012	0.0024	0.00058	0.023	0.0023	0.0006
0.02	0.013	0.0020	0.0003	0.010	0.0011	0.0003	0.021	0.0027	0.0004
0.03	0.012	0.0017	0.0002	0.009	0.0012	0.0002	0.022	0.0025	0.0004
0.04	0.011	0.0014	0.0002	0.007	0.0010	0.0002	0.022	0.0025	0.0006
0.05	0.011	0.0013	0.0002	0.011	0.0008	0.0002	0.021	0.0026	0.0002
0.1	0.011	0.0010	0.0001	0.009	0.0008	0.0001	0.021	0.0024	0.0003
0.2	0.010	0.0010	0.0001	0.010	0.0010	0.0001	0.019	0.0033	0.0004
0.3	0.010	0.0010	0.0001	0.011	0.0013	0.0001	0.021	0.0033	0.0011

ISSN: 1471-2164