Fig. 2

Gene-expression profile and interactome analyses of the Expanded gene set from the Brown and White pathway genes. (A) Heatmaps show separately the relative gene-expression profile of the genes enriched in the Brown, the White, and both the Brown and White pathways (Linker genes) in differentiated adipocytes and (B) in preadipocytes and differentiated adipocytes based on the presence of FTO obesity-risk alleles; we used samples with FTO T/T-risk-free (donor 1–3) and C/C-obesity-risk alleles (donor 7–9) and left out the FTO T/C heterozygous samples (donor 4–6), which are shown for some cases in the paper Tóth et al., 2020. B: Brown differentiation; W: White differentiation; SC: Subcutaneous; DN: Deep-neck (C) Interactome of the 3705 Brown and White Pathways proteins; Interaction score confidence value: 0.4. (D) List of 25–25 proteins that occupy a pivotal position in the interactome based on the betweenness centrality score (betweenness) and the number of bridges (n.bridges) from network analyses of the Brown or the White pathway proteins. Magenta Highlights the Linker-proteins that occupy a pivotal position in the interactome based on the Brown or White pathway proteins. (E) The relative gene-expression profile of the 25–25 proteins with the highest betweenness centrality score and number of bridges from the Brown and White pathway proteins based on the presence of the FTO obesity-risk allele. Magenta highlights the linker proteins