Fig. 3

The list, Interactome analysis and relative gene-expression profile of the 30 proteins with the highest number of bridges in the network of the Expanded gene set. (A) The list of the 30 proteins with the highest NUMBER of BRIDGES score (core module-proteins) based on the interactome network analyses of the expanded protein-sets (3705 proteins) (B) Interactome of the 30 core-module proteins, the color of nodes marks the enriched pathways, and the color of rings shows the type of the phenotype the protein belongs; red: brown expanded protein-set, blue: white expanded protein-set, magenta: linker proteins; right panel lists the enriched signaling pathways, the number of proteins (NP) belonging to this pathway from the 30 core-module proteins and the significance level of the enrichment with False Discovery Rate value (FDR). (C) Gene-expression profile of the 30 core-module proteins, right panel marks genes that belong to expanded Brown gene set (red), expanded White gene set (blue), Linker genes (magenta), HIF1A pathway (green), and PIP3-AKT (yellow) pathway