Table 1 Common KEGG and REACTOME enriched pathways in BATLAS and ProFAT brown Marker-genes. Table 1 shows the 21 KEGG and 21 REACTOME pathways that were enriched in both BATLAS and ProFAT brown-markers
Common KEGG enriched pathways in ProFAT and BATLAS Brown Marker-genes | Common REACTOM enriched pathways in BATLAS and ProFAT Brown Marker-genes |
|---|---|
Metabolic pathways | The citric acid (TCA) cycle and respiratory electron transport |
Citrate cycle (TCA cycle) | Metabolism |
Carbon metabolism | Pyruvate metabolism and Citric Acid (TCA) cycle |
Thermogenesis | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
Parkinson’s disease | Citric acid cycle (TCA cycle) |
Huntington’s disease | Respiratory electron transport |
Oxidative phosphorylation | Complex I biogenesis |
Non-alcoholic fatty liver disease (NAFLD) | Mitochondrial Fatty Acid Beta-Oxidation |
Alzheimer’s disease | Fatty acid metabolism |
Biosynthesis of amino acids | Glyoxylate metabolism and glycine degradation |
2-Oxocarboxylic acid metabolism | mitochondrial fatty acid beta-oxidation of saturated fatty acids |
Fatty acid metabolism | Regulation of pyruvate dehydrogenase (PDH) complex |
Retrograde endocannabinoid signaling | Beta oxidation of hexanoyl-CoA to butanoyl-CoA |
Pyruvate metabolism | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA |
Fatty acid degradation | Signaling by Retinoic Acid |
Valine, leucine and isoleucine degradation | Metabolism of lipids |
Fatty acid elongation | Mitochondrial protein import |
Glyoxylate and dicarboxylate metabolism | Lysine catabolism |
Glycolysis / Gluconeogenesis | Metabolism of amino acids and derivatives |
Cardiac muscle contraction | Branched-chain amino acid catabolism |
PPAR signaling pathway | Transcriptional activation of mitochondrial biogenesis |