Fig. 4

Associated motif interaction networks for AP1/MAF, TEAD, and FOX families in enhancer regions. A) Dot plot indicating significance of the indicated interrogated motif in the AP1/MAF family of TFs at either D0 (light blue), D4 (medium blue), or D6 (dark blue). Size of dot is reflective of RPKM expression level at the indicated day. RPKMs are an average of all three donors profiled by RNAseq. B) Stacked histogram of factors whose motifs were associated with the AP1/MAF family member FOS. TF families are colored according to conserved binding sequence. C) Significance of the indicated TFBS motif associated with FOS in D0, D4, and D6 enhancer regions. A representative factor from each family of TFs is shown. D) Dot plot indicating significance of the indicated interrogated motif in the TEAD family of TFs at either D0 (lilac), D4 (purple), or D6 (indigo). Size of dot is reflective of RPKM expression level at the indicated day. RPKMs are an average of all three donors profiled by RNAseq. E) Stacked histogram of factors whose motifs were associated with the TEAD family member FOS. TF families are colored according to conserved binding sequence as in (B). F) Significance of the indicated TFBS motif associated with TEAD in D0, D4, and D6 enhancer regions. A representative factor from each family of TFs is shown. G) Dot plot indicating significance of the indicated interrogated motif in the FOX family of TFs at either D0 (light teal), D4 (medium teal), or D6 (dark teal). Size of dot is reflective of RPKM expression level at the indicated day. RPKMs are an average of all three donors profiled by RNAseq. H) Stacked histogram of factors whose motifs were associated with the FOX family member FOXP1. TF families are colored according to conserved binding sequence. I) Significance of the indicated TFBS motif associated with FOXP1 in D0, D4, and D6 enhancer regions. A representative factor from each family of TFs is shown