Skip to main content
Fig. 6 | BMC Genomics

Fig. 6

From: Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity

Fig. 6

Comparative analysis of AEC enhancers with ROADMAP and ENCODE enhance-ome reveals 237 alveolar epithelial-specific enhancers. A) Diffbind plotting of similarity between enhancer regions. Tissue = ROADMAP or ENCODE indicated cell type. Stage = age of donor, subdivided into pre- and post- natal. Source = origin of the data used in the analysis. B) Three-dimensional scatterplot of enrichment for each of the TFBS present in HOMER in AT2, AT1-like, and HMEC enhancers. Red scale coloring indicates level of enrichment in HMEC. Grey circle indicates TFBS motifs enriched in all 3 cell types. Blue circle indicates TFBS enriched in HMEC and AT1-like cells, green circle indicates TFBS motifs enriched specifically in AT2 and AT1-like cells. C) Pie chart indicating similarity between ROADMAP/ENCODE enhancers and AEC-identified enhancers. AEC = regions labeled enhancers in both AT2 and AT1-like cells but not in any ROADMAP or ENCODE dataset. D) Histogram indicating tag-density of enhancer-specific enrichment for H3K27Ac between biological replicates. E) Distribution of AT2 and AT1-like cell-specific enhancer regions genome-wide

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us